Department of General Medicine, Asahikawa Medical University, 2-1-1 Midorigaoka-Higashi, Asahikawa, 078-8510, Japan.
Rheumatol Int. 2012 Jun;32(6):1695-9. doi: 10.1007/s00296-011-1849-3. Epub 2011 Mar 24.
We analyzed the rate of polymyalgia rheumatica (PMR) and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome, both characterized as seronegative inflammatory arthritis in elderly, in an outpatient unit where primary care physicians are working in Japan to better understand the epidemiological characteristics of the diseases in Japan. Consecutive outpatients who newly visited at Department of General Medicine, Asahikawa Medical University Hospital, Japan, between April 2004 and March 2010 were analyzed. Each parameter such as age, sex, diagnosis, and biochemical examination was investigated. During the 6 years, 10 or 3 patients were diagnosed as PMR or RS3PE syndrome, respectively. The patients with PMR were 7 women and 3 men, and the average age at diagnosis was 69. Out of all patients aged over 50 (n = 3,347), the rate of PMR was 0.22% in men or 0.36% in women, respectively. On the other hand, RS3PE syndrome was diagnosed in 3 men (76, 76, and 81 years old). The rate of patients with RS3PE syndrome was 0.09% among outpatients aged over 50 indicating that the rate of PMR in an outpatient clinic in Japan is not far from previous findings reported from western countries. When compared with PMR, the rate of RS3PE syndrome was approximately one-third, providing for the first time the rate of RS3PE syndrome when compared with PMR. These epidemilogical data might help us pick up the diseases in primary care setting in Japan.
我们分析了在日本的一个门诊单位中，以原发性保健医生工作的门诊患者为对象，肌痛性风湿症（PMR）和缓解型血清阴性对称性滑膜炎伴凹陷性水肿（RS3PE）综合征的发生率，这两种疾病的特征均为老年人群中的血清阴性炎症性关节炎。分析了 2004 年 4 月至 2010 年 3 月期间在日本旭川医科大学综合医学科新就诊的连续门诊患者。调查了每个患者的年龄、性别、诊断和生化检查等参数。在 6 年期间，分别有 10 例或 3 例患者被诊断为 PMR 或 RS3PE 综合征。PMR 患者中，女性 7 例，男性 3 例，诊断时的平均年龄为 69 岁。在所有年龄超过 50 岁的患者（n=3347）中，男性或女性的 PMR 发生率分别为 0.22%或 0.36%。另一方面，诊断出 3 例 RS3PE 综合征患者（年龄分别为 76、76 和 81 岁）。在年龄超过 50 岁的门诊患者中，RS3PE 综合征患者的比例为 0.09%，表明日本门诊中 PMR 的发生率与西方国家的既往报道结果相差不大。与 PMR 相比，RS3PE 综合征的发生率约为其三分之一，首次提供了 RS3PE 综合征与 PMR 发生率的比较数据。这些流行病学数据可能有助于我们在日本的初级保健环境中发现这些疾病。
