Cao Ying, Sun Yang, Liu Xiao, Yu Kang, Gao Danyang, Yang Jiaojiao, Miao Huihui, Li Tianzuo
Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Front Neurol. 2023 Apr 27;14:1185900. doi: 10.3389/fneur.2023.1185900. eCollection 2023.
The neurotoxicity effects of anesthetic exposure on the developing brain have been one of the current research hotspots and numerous articles were published in the past decades. However, the quality and comparative information of these articles have not been reported. This research aimed to provide a comprehensive overview of the current state of the field by investigating research hotspots and publication trends concerning the neurotoxicity of anesthesia in the developing brain.
On 15 June 2022, we searched articles on the neurotoxicity of anesthesia in the developing brain through the Science Citation Index databases from 2002 to 2021. Data of the author, title, publication, funding agency, date of publication, abstract, type of literature, country, journal, keywords, number of citations, and research direction were collected for further analysis.
We searched and analyzed 414 articles in English on the field of neurotoxicity of anesthesia in the developing brain from 2002 to 2021. The country with the largest number of publications was The United States (US) ( = 226), which also had the largest total number of citations (10,419). Research in this field reached a small peak in 2017. Furthermore, the largest number of articles were published in three journals, Anesthesiology, Anesthesia and Analgesia, and Pediatric Anesthesia. The top 20 articles that were cited most often were studied. In addition, the top hotspots of this area in clinical investigations and basic research were analyzed separately.
This study provided an overview of the development in the neurotoxicity of anesthesia in the developing brain using bibliometric analysis. Current clinical studies in this area were mainly retrospective; in the future, we should place more emphasis on prospective, multicenter, long-term monitoring clinical studies. More basic research was also needed on the mechanisms of neurotoxicity of anesthesia in the developing brain.
麻醉暴露对发育中大脑的神经毒性作用一直是当前的研究热点之一，在过去几十年发表了大量文章。然而，这些文章的质量和比较信息尚未见报道。本研究旨在通过调查发育中大脑麻醉神经毒性的研究热点和发表趋势，全面概述该领域的现状。
2022年6月15日，我们通过科学引文索引数据库检索了2002年至2021年关于发育中大脑麻醉神经毒性的文章。收集作者、标题、出版物、资助机构、出版日期、摘要、文献类型、国家、期刊、关键词、被引次数和研究方向等数据进行进一步分析。
我们检索并分析了2002年至2021年期间关于发育中大脑麻醉神经毒性领域的414篇英文文章。发表文章数量最多的国家是美国（226篇），其总被引次数也最多（10419次）。该领域的研究在2017年达到一个小高峰。此外，发表文章数量最多的三本期刊是《麻醉学》《麻醉与镇痛》和《小儿麻醉》。研究了被引次数最多的前20篇文章。此外，还分别分析了该领域临床研究和基础研究的前十大热点。
本研究采用文献计量学分析方法概述了发育中大脑麻醉神经毒性的研究进展。该领域目前的临床研究主要是回顾性的；未来，我们应更加重视前瞻性、多中心、长期监测的临床研究。还需要对发育中大脑麻醉神经毒性的机制进行更多的基础研究。
