Li Xiaoqin, Tan Lin, Chen Yingyi, Qin Xinyan, Fan Ze
Department of Anaesthesiology and Perioperative Medicine, The First Affiliated Hospital of the Air Force Medical University, Xi'an, CHN.
Department of Medical Ethics, College of Basic Medicine, Fourth Military Medical University, Xi'an, CHN.
Cureus. 2024 Apr 17;16(4):e58490. doi: 10.7759/cureus.58490. eCollection 2024 Apr.
The impact of general anesthetics on brain function development is one of the top frontier issues of public concern. However, little bibliometric analysis has investigated this territory systematically. Our study aimed to visualize the publications between 2000 and 2023 to inspire the trends and hotspots in anesthetic neurodevelopmental toxicity research. Publications from 2000 to 2023 were collected from the Web of Science Core Collection. CiteSpace was utilized to plot and analyze the network maps of countries, institutions, authors, journals, and keywords associated with these publications. A total of 864 publications, consisting of 786 original articles and 78 reviews, were extracted from 2000 to 2023. The annual publications have increased constantly over the past two decades. The USA and the People's Republic of China were the leading driving forces in this field. Harvard University was the most productive institution. Zhang Y published the most related articles, and Jevtovic-Todorovic V was mostly cited in this field. The most prolific journal was Pediatric Anesthesia, and the most frequently co-cited journal was Anesthesiology. Keywords were divided into nine clusters: "apoptosis", "propofol", "developing brain", "cognitive dysfunction", "neuronal cell degeneration", "brain", "neuroinflammation", "local anesthesia", and "oxygen therapy". The strongest citation bursts in earlier years were "learning disability", "cell death", and "cognitive function". The emerging trends in the coming years were "awake regional anesthesia", "behavioral outcome", and "infancy general anesthesia compared to spinal anesthesia". We conclude that anesthetic-induced neurotoxicity has received growing attention in the past two decades. Our findings evaluated the present status and research trends in this area, which may provide help for exploring further potential prospects on hot topics and frontiers.
全身麻醉对脑功能发育的影响是公众关注的前沿热点问题之一。然而，很少有文献计量分析对该领域进行系统研究。我们的研究旨在可视化2000年至2023年的相关出版物，以揭示麻醉神经发育毒性研究的趋势和热点。从Web of Science核心合集中收集了2000年至2023年的出版物。利用CiteSpace绘制并分析与这些出版物相关的国家、机构、作者、期刊和关键词的网络图。2000年至2023年共提取了864篇出版物，其中包括786篇原创文章和78篇综述。在过去二十年中，年出版物数量持续增加。美国和中华人民共和国是该领域的主要推动力量。哈佛大学是产出最多的机构。张Y发表的相关文章最多，Jevtovic-Todorovic V在该领域被引用次数最多。发文量最多的期刊是《小儿麻醉》，被共同引用次数最多的期刊是《麻醉学》。关键词分为九个聚类：“细胞凋亡”“丙泊酚”“发育中的大脑”“认知功能障碍”“神经元细胞变性”“大脑”“神经炎症”“局部麻醉”和“氧疗”。早年最强的引用爆发词是“学习障碍”“细胞死亡”和“认知功能”。未来几年的新兴趋势是“清醒区域麻醉”“行为结果”以及“婴儿全身麻醉与脊髓麻醉的比较”。我们得出结论，在过去二十年中，麻醉诱导的神经毒性受到了越来越多的关注。我们的研究结果评估了该领域的现状和研究趋势，这可能有助于探索热点话题和前沿领域的进一步潜在前景。
