脑脊液葡萄糖的每小时分析显示出较大的昼夜波动。
Hourly analysis of cerebrospinal fluid glucose shows large diurnal fluctuations.
作者信息
Verbeek Marcel M, Leen Wilhelmina G, Willemsen Michèl A, Slats Diane, Claassen Jurgen A
机构信息
Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlandsv Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands
Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlandsv Department of Pediatric Neurology, Radboud University Medical Center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
出版信息
J Cereb Blood Flow Metab. 2016 May;36(5):899-902. doi: 10.1177/0271678X16637612. Epub 2016 Mar 4.
Cerebrospinal fluid analysis is important in the diagnostics of many neurological disorders. Since the influence of food intake on the cerebrospinal fluid glucose concentration and the cerebrospinal fluid/plasma glucose ratio is largely unknown, we studied fluctuations in these parameters in healthy adult volunteers during a period of 36 h. Our observations show large physiological fluctuations of cerebrospinal fluid glucose and the cerebrospinal fluid/plasma glucose ratio, and their relation to food intake. These findings provide novel insights into the physiology of cerebral processes dependent on glucose levels such as energy formation (e.g. glycolysis), enzymatic reactions (e.g. glycosylation), and non-enzymatic reactions (e.g. advanced endproduct glycation).
脑脊液分析在许多神经系统疾病的诊断中具有重要意义。由于食物摄入对脑脊液葡萄糖浓度和脑脊液/血浆葡萄糖比值的影响在很大程度上尚不清楚，我们对健康成年志愿者在36小时内这些参数的波动情况进行了研究。我们的观察结果显示，脑脊液葡萄糖和脑脊液/血浆葡萄糖比值存在较大的生理波动，以及它们与食物摄入的关系。这些发现为依赖葡萄糖水平的脑过程生理机制提供了新的见解，如能量生成（如糖酵解）、酶促反应（如糖基化）和非酶促反应（如晚期糖基化终末产物的形成）。
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