Jirakran Ketsupar, Vasupanrajit Asara, Tunvirachaisakul Chavit, Maes Michael
PhD Programme in Mental Health, Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Front Psychiatry. 2023 Apr 26;14:1158036. doi: 10.3389/fpsyt.2023.1158036. eCollection 2023.
Neuroticism, a personality trait, can predict major depressive disorder (MDD). The current study aims to determine whether a) neuroticism is a feature of the acute state of MDD, including suicidal behaviors (SB); and b) adverse childhood experiences (ACEs) are associated with neuroticism in MDD.
This study included 133 participants, 67 healthy controls and 66 MDD patients, and assessed the Big 5 Inventory (BFI), ACEs using the ACE Questionnaire, and the phenome of depression using the Hamilton Depression Rating Scale (HAM-D), Beck Depression Inventory (BDI), The State-Trait Anxiety Inventory (STAI) and Columbia Suicide Severity Rating Scale (C-SSRS) scores to assess current SB.
Neuroticism was significantly higher in MDD than controls, and it explained 64.9% of the variance in the depression phenome (a latent vector extracted from HAM-D, BDI, STAI, and current SB scores). The other BFI domains had much less (extraversion, agreeableness) or no effect (openness, conscientiousness). One latent vector could be extracted from the phenome, lifetime dysthymia, lifetime anxiety disorders and neuroticism scores. Neglect (physical and emotional) and abuse (physical, neglect and sexual) account for approximately 30% of the variance in this latent vector. Partial Least Squares analysis showed that the effects of neglect on the phenome were partially mediated by neuroticism, whereas the effects of abuse were completely mediated by neuroticism.
Neuroticism (trait) and the MDD phenome (state) are both manifestations of the same latent core, with neuroticism being a subclinical manifestation of MDD.
神经质作为一种人格特质，能够预测重度抑郁症（MDD）。本研究旨在确定：a）神经质是否为MDD急性期的一个特征，包括自杀行为（SB）；以及b）童年不良经历（ACEs）是否与MDD中的神经质相关。
本研究纳入了133名参与者，其中67名健康对照者和66名MDD患者，使用大五人格量表（BFI）、通过ACE问卷评估ACEs，并使用汉密尔顿抑郁量表（HAM-D）、贝克抑郁量表（BDI）、状态-特质焦虑量表（STAI）和哥伦比亚自杀严重程度评定量表（C-SSRS）评分评估抑郁现象及当前的SB情况。
MDD患者的神经质显著高于对照组，且它解释了抑郁现象（从HAM-D、BDI、STAI和当前SB评分中提取的一个潜在向量）中64.9%的变异。BFI的其他维度影响较小（外向性、宜人性）或无影响（开放性、尽责性）。从抑郁现象、终生心境恶劣障碍、终生焦虑症和神经质评分中可提取出一个潜在向量。忽视（身体和情感方面）以及虐待（身体、忽视和性方面）约占该潜在向量中30%的变异。偏最小二乘法分析表明，忽视对抑郁现象的影响部分由神经质介导，而虐待的影响完全由神经质介导。
神经质（特质）和MDD现象（状态）都是同一潜在核心的表现，神经质是MDD的亚临床表现。
