Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Spain.
Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Spain.
Mech Ageing Dev. 2023 Jun;212:111822. doi: 10.1016/j.mad.2023.111822. Epub 2023 May 12.
In the past years, microRNAs (miRNAs) have emerged as important biomarkers and essential regulators of many pathophysiological processes. Several studies have focused on the importance of these noncoding RNAs (ncRNAs) in maintaining mitochondrial function, introducing the term mitochondrial microRNAs (mitomiRs) to refer to those miRNAs controlling mitochondrial activity, either by targeting cytoplasmatic messenger RNAs (mRNAs) or by acting inside the mitochondria. Mitochondrial homeostasis is paramount in the cardiovascular system, where an important energy supply is needed to maintain the homeostasis of tissues, such as the myocardium. In this review, we will address the relevance of mitomiRs in cardiovascular pathologies by dissecting and categorizing their effect in mitochondrial function in order to provide a robust framework for new mitomiR-based therapeutical approaches to this group of diseases.
在过去的几年中，microRNAs（miRNAs）已成为许多病理生理过程的重要生物标志物和关键调节因子。多项研究集中在这些非编码 RNA（ncRNAs）在维持线粒体功能方面的重要性，引入了“线粒体 microRNAs（mitomiRs）”这一术语，用于指代那些通过靶向细胞质信使 RNA（mRNA）或在线粒体内部发挥作用来控制线粒体活性的 miRNAs。线粒体的动态平衡在心血管系统中至关重要，因为需要重要的能量供应来维持组织（如心肌）的动态平衡。在这篇综述中，我们将通过剖析和分类它们对线粒体功能的影响，探讨 mitomiRs 在心血管疾病中的相关性，为这组疾病的新的基于 mitomiR 的治疗方法提供一个稳健的框架。
