Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
J Gerontol A Biol Sci Med Sci. 2024 Apr 1;79(4). doi: 10.1093/gerona/glae058.
Aging is a multifactorial process characterized by an age-related decline in organismal fitness. This deterioration is the major risk factor for chronic diseases such as cardiovascular pathologies, neurodegeneration, or cancer, and it represents one of the main challenges of modern society. Therefore, understanding why and how we age would be a fundamental pillar to design strategies to promote a healthy aging. In the last decades, the study of the molecular bases of disease has been revolutionized by the discovery of different types of noncoding RNAs (ncRNAs) with regulatory potential. In this work, we will review the implication of ncRNAs in aging, with the aim to provide a first approach to the different aging-associated ncRNAs, their mechanism of action, and their potential relevance as therapeutic targets and disease biomarkers.
衰老是一个多因素的过程，其特征是与年龄相关的机体功能下降。这种恶化是心血管病理、神经退行性变或癌症等慢性疾病的主要危险因素，也是现代社会面临的主要挑战之一。因此，了解我们为什么会衰老以及如何衰老将是设计促进健康衰老策略的重要基础。在过去的几十年中，随着不同类型具有调节潜力的非编码 RNA（ncRNA）的发现，疾病的分子基础研究发生了革命性的变化。在这项工作中，我们将综述 ncRNA 在衰老中的作用，旨在为不同与衰老相关的 ncRNA 及其作用机制提供一个初步的研究，以及它们作为治疗靶点和疾病生物标志物的潜在相关性。
