线粒体非编码 RNA：旧瓶中的新酒。
Mitochondrial noncoding RNAs: new wine in an old bottle.
机构信息
Department of Infectious Diseases, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
Guangdong Provincial Key Laboratory of Liver Disease Research, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
出版信息
RNA Biol. 2021 Dec;18(12):2168-2182. doi: 10.1080/15476286.2021.1935572. Epub 2021 Jun 10.
Abstract
Mitochondrial noncoding RNAs (mt-ncRNAs) include noncoding RNAs inside the mitochondria that are transcribed from the mitochondrial genome or nuclear genome, and noncoding RNAs transcribed from the mitochondrial genome that are transported to the cytosol or nucleus. Recent findings have revealed that mt-ncRNAs play important roles in not only mitochondrial functions, but also other cellular activities. This review proposes a classification of mt-ncRNAs and outlines the emerging understanding of mitochondrial circular RNAs (mt-circRNAs), mitochondrial microRNAs (mitomiRs), and mitochondrial long noncoding RNAs (mt-lncRNAs), with an emphasis on their identification and functions.
摘要
线粒体非编码 RNA（mt-ncRNAs）包括来自线粒体基因组或核基因组转录的线粒体内部非编码 RNA，以及从线粒体基因组转录并转运到细胞质或核内的非编码 RNA。最近的研究发现，mt-ncRNAs 不仅在线粒体功能中发挥重要作用，而且在其他细胞活动中也发挥重要作用。本综述提出了 mt-ncRNAs 的分类，并概述了线粒体环状 RNA（mt-circRNAs）、线粒体 microRNAs（mitomiRs）和线粒体长非编码 RNA（mt-lncRNAs）的新认识，重点介绍了它们的鉴定和功能。
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