Department of Analytical Chemistry, Sciences Faculty, University of Granada, E-18071 Granada, Spain.
Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, E-41011 Seville, Spain.
Environ Toxicol Pharmacol. 2023 Jun;100:104147. doi: 10.1016/j.etap.2023.104147. Epub 2023 May 12.
The present work assess the bioconcentration kinetics of atenolol (ATN) and carbamazepine (CBZ) in common marine organisms including Holothuria tubulosa, Anemonia sulcata and Actinia equina under controlled laboratory conditions. CBZ exhibited higher uptake and excretion rates resulting higher bioconcentration factor (BCF) (41-537 L/kg for CBZ vs 7-50 L/kg for ATN) although both are below the limits established by the European Union (EU). The measured BCF using kinetic data showed some differences with those predicted using the concentrations measured at the steady-state, probably explained because the steady state was not ready reached. The animal-specific BCF followed the order of Holothuria tubulosa > Actinia equina > Anemonia sulcata for ATN while was the opposite for CBZ. The study highlighted between-tissues differences in the digestive tract and the body wall of the Holothuria tubulosa. The work presented is the first to model bioconcentration of ATN and CBZ in holothurian and anemone animal models.
本研究评估了普萘洛尔（ATN）和卡马西平（CBZ）在包括海参、海葵和海鸡冠在内的常见海洋生物中的生物浓缩动力学，在受控实验室条件下进行。CBZ 表现出更高的摄取和排泄速率，导致更高的生物浓缩因子（BCF）（CBZ 的 BCF 为 41-537 L/kg，而 ATN 的 BCF 为 7-50 L/kg），尽管两者均低于欧盟（EU）规定的限值。使用动力学数据测量的 BCF 与使用稳态下测量的浓度预测的 BCF 存在一些差异，这可能是因为尚未达到稳态。ATN 的动物特异性 BCF 遵循海参>海鸡冠>海葵的顺序，而 CBZ 则相反。本研究强调了海参消化道和体壁组织之间的差异。本工作首次在海参和海葵动物模型中对 ATN 和 CBZ 的生物浓缩进行了建模。
