School of Architecture and Fine Art, Dalian University of Technology, Dalian, China.
School of Jiang He Architecture, Northeastern University, Shenyang, China.
J Alzheimers Dis. 2023;93(4):1223-1235. doi: 10.3233/JAD-221204.
Depression is one of the most common symptoms in patients with dementia.
This meta-analysis aimed to evaluate the effect of light therapy on depression associated with dementia by using a single scale.
Published studies based on the terms including "Dementia", "depression", and "Phototherapy" were searched. Web of Science, PubMed, Embase, CiNii, CNKI, Wanfang Database, and China Biology Medicine disc were adopted to collect randomized controlled studies or cross-controlled studies using the Cornell Scale for Depression in Dementia (CSDD) until February 2022. GRADE and Review Manager Version 5.4.1 were employed to assess the risk of bias. A meta-analysis was conducted by R 4.0.2 software based on the changes in CSDD scores.
A total of 1,055 studies were retrieved from the databases, and six studies were included after screening. Some 406 people with dementia were included with an average age of over 80 years. Forest plot results showed that light intervention improved depression scores of dementia patients (MD = -2.59, 95% CI: -4.46 to -0.71), and light intensity less than 1,000 lux improved depression symptoms of dementia patients (MD = -2.76, 95% CI: -4.55 to -0.97). An intervention that lasted 8 to 12 weeks was the most effective (MD = -3.77, 95% CI: -6.93 to -0.60), and non-stable interventions such as ceiling LED lights exerted more positive effects (MD = -2.12, 95% CI: -3.38 to -0.85).
The overall results of the meta-analysis suggested that light intervention can improve the depressive symptoms of older patients with dementia.
抑郁症是痴呆患者最常见的症状之一。
本荟萃分析旨在使用单一量表评估光疗对与痴呆相关的抑郁的影响。
使用“痴呆”、“抑郁”和“光疗”等术语搜索已发表的研究。通过 Web of Science、PubMed、Embase、CiNii、CNKI、万方数据库和中国生物医学文献数据库，收集截至 2022 年 2 月使用 Cornell 痴呆抑郁量表（CSDD）的随机对照研究或交叉对照研究。采用 GRADE 和 Review Manager Version 5.4.1 评估偏倚风险。使用 R 4.0.2 软件基于 CSDD 评分的变化进行荟萃分析。
从数据库中检索到 1055 项研究，筛选后纳入 6 项研究。共有 406 名痴呆患者纳入研究，平均年龄超过 80 岁。森林图结果显示，光照干预可改善痴呆患者的抑郁评分（MD=-2.59，95%CI：-4.46 至-0.71），光照强度低于 1000 勒克斯可改善痴呆患者的抑郁症状（MD=-2.76，95%CI：-4.55 至-0.97）。干预持续 8 至 12 周的效果最显著（MD=-3.77，95%CI：-6.93 至-0.60），非稳定干预（如天花板 LED 灯）效果更为积极（MD=-2.12，95%CI：-3.38 至-0.85）。
荟萃分析的总体结果表明，光疗可以改善老年痴呆症患者的抑郁症状。
