Sacks E, Worgul B V, Merriam G R, Hilal S
Arch Ophthalmol. 1986 Jun;104(6):890-3. doi: 10.1001/archopht.1986.01050180124043.
Nuclear magnetic resonance, an imaging technique with great promise for detecting cerebral abnormalities, was studied to determine its possible deleterious effects on the mammalian eye. Young (3.5-week-old) Columbia-Sherman rats were exposed simultaneously to a constant magnetic field of 2.7 tesla and radio frequency pulses of 29 MHz at 800-ms intervals for six hours at field strengths representing the maximum used in a clinical setting. The six-hour exposure is many times greater than the four to six minutes currently employed in most diagnostic protocols. The animals were examined by slit-lamp biomicroscopy and ophthalmoscopy at regular intervals. Autoradiograms of lenses from animals injected with tritiated thymidine prior to exposure did not reveal any disturbances in cell-cycle kinetics. Eyes from rats not previously injected with the isotope were processed for cytopathologic analysis at various intervals. A two-year follow-up has indicated that at both the slit-lamp biomicroscopic and the light microscopic levels, there were no discernable effects on the rat eye.
核磁共振是一种在检测脑部异常方面极具潜力的成像技术，对其可能对哺乳动物眼睛产生的有害影响进行了研究。选用年轻的（3.5周龄）哥伦比亚-谢尔曼大鼠，在代表临床应用中最大使用场强的条件下，同时暴露于2.7特斯拉的恒定磁场和间隔800毫秒的29兆赫兹射频脉冲下6小时。这6小时的暴露时间比目前大多数诊断方案中使用的4至6分钟要长得多。定期通过裂隙灯生物显微镜检查和检眼镜检查对动物进行检查。对在暴露前注射了氚标记胸腺嘧啶核苷的动物的晶状体进行放射自显影，未发现细胞周期动力学有任何紊乱。对之前未注射该同位素的大鼠的眼睛在不同时间间隔进行细胞病理学分析。两年的随访表明，在裂隙灯生物显微镜检查和光学显微镜检查水平上，对大鼠眼睛均未发现明显影响。
