Norouzi Fatemeh, Alizadeh Ismaeil, Faraji Maryam
Department of Environmental Health Engineering, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran.
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
Thyroid Res. 2023 May 15;16(1):13. doi: 10.1186/s13044-023-00153-9.
Thyroid cancer is considered as one of the most prevalent cancers in the world. Some pesticides can play a role as a potentially important risk factor in thyroid cancer by affecting thyroid morphology and thyroid hormone homeostasis. The aim of present study was to systematically review the available epidemiological evidence for human exposure to pesticides and thyroid cancer. Articles were searched in PubMed, Scopus and Web of Science by suitable keywords from January 2000 to May 2021. Standard techniques for systematic reviews were followed in the current study and results reported according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Based on the inclusion and exclusion criteria, finally seven studies including four cohort studies and three case-control studies were reviewed. Organochlorines (OCPs) in more cases, Organophosphates (OPs) and Carbamates insecticides, herbicides and fungicides were the studied pesticides. Inconsistent results were reported in the surveyed articles on the OCPs. Two articles on the Carbamates (Carbaryl and Mancozeb) showed consistently an inverse association between exposure and thyroid cancer. Increased risk of thyroid cancer due to the exposure to the Malathion was reported in one article on the OPs. Due to the limited current knowledge about the effect of pesticides on thyroid cancer in humans, human health policies must be implemented to control individual's exposure to chemicals through using of botanical pesticides in agricultural. Also, more studies must be done to fill this gap of knowledge.
甲状腺癌被认为是全球最常见的癌症之一。一些农药可通过影响甲状腺形态和甲状腺激素稳态，成为甲状腺癌潜在的重要风险因素。本研究的目的是系统回顾有关人类接触农药与甲状腺癌的现有流行病学证据。2000年1月至2021年5月期间，通过合适的关键词在PubMed、Scopus和Web of Science中检索文章。本研究遵循系统评价的标准技术，并根据系统评价和Meta分析的首选报告项目（PRISMA）指南报告结果。根据纳入和排除标准，最终回顾了七项研究，包括四项队列研究和三项病例对照研究。所研究的农药大多为有机氯（OCPs）、有机磷（OPs）以及氨基甲酸酯类杀虫剂、除草剂和杀菌剂。在所调查的关于OCPs的文章中报告的结果不一致。两篇关于氨基甲酸酯类（西维因和代森锰锌）的文章始终表明暴露与甲状腺癌之间存在负相关。一篇关于OPs的文章报告了因接触马拉硫磷而增加的甲状腺癌风险。由于目前关于农药对人类甲状腺癌影响的知识有限，必须实施人类健康政策，通过在农业中使用植物源农药来控制个体对化学品的接触。此外，必须开展更多研究来填补这一知识空白。
