Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Cell Physiol. 2023 Jul;238(7):1416-1430. doi: 10.1002/jcp.31031. Epub 2023 May 14.
Sarcopenia is an elderly disease and is related to frailty and loss of muscle mass (atrophy) of older adults. The exact molecular mechanisms contributing to the pathogenesis of disease are yet to be discovered. In recent years, the role of noncoding RNAs in the pathogenesis of almost every kind of malignant and nonmalignant conditions is pinpointed. Regarding their regulatory function, there have been an increased number of studies on the role of noncoding RNAs in the progress of sarcopenia. In this manuscript, we review the role of microRNAs and long noncoding RNAs in development and progression of disease. We also discuss their potential as therapeutic targets in this condition.
肌肉减少症是一种老年疾病，与老年人的虚弱和肌肉质量（萎缩）损失有关。导致疾病发生的确切分子机制尚待发现。近年来，非编码 RNA 在几乎所有恶性和非恶性疾病发病机制中的作用已被明确指出。关于它们的调节功能，越来越多的研究关注非编码 RNA 在肌肉减少症进展中的作用。在本文中，我们综述了 microRNAs 和长链非编码 RNA 在疾病发生和发展中的作用。我们还讨论了它们在这种情况下作为治疗靶点的潜力。
