Yang Gu, Wu Yanjiao, Wan Rongxue, Sang Hongxun, Liu Huan, Huang Wenhua
Guangdong Innovation Platform for Translation of 3D Printing Application, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510000, P.R. China.
Shunde Hospital, Southern Medical University (The First People's Hospital of Shun de), Foshan, Guangdong 528000, P.R. China.
Int J Oncol. 2021 Sep;59(3). doi: 10.3892/ijo.2021.5249. Epub 2021 Jul 23.
Osteosarcoma (OS) is the most common primary bone tumor worldwide. OS exhibits a range of aggressive behaviors, including early metastasis potential, rapid progression, poor clinical prognosis and insensitivity to chemoradiotherapy. Non‑coding RNAs are transcripts that do not encode proteins. A significant number of studies published on OS have been focused on the aberrant expression of non‑coding RNAs and their involvement in tumor initiation and progression. It has been confirmed that non‑coding RNAs exert their regulatory functions at both the transcriptional and post‑transcriptional level, which leads to tumor initiation or progression in OS. According to present knowledge, this review provides a state‑of‑the‑art overview of the functions and mechanisms of microRNAs, long non‑coding RNAs and circular RNAs in terms of their involvement with OS. The review also covers their potential clinical application in the diagnosis, prognosis and treatment of OS. It is hoped that the information presented in this review on the involvement of non‑coding RNAs in OS will lead to a more comprehensive understanding of OS and provide a useful perspective on the potential diagnostic and therapeutic applications of non‑coding RNAs for patients with OS.
骨肉瘤（OS）是全球最常见的原发性骨肿瘤。骨肉瘤表现出一系列侵袭性行为，包括早期转移潜能、快速进展、临床预后差以及对放化疗不敏感。非编码RNA是不编码蛋白质的转录本。大量关于骨肉瘤的研究聚焦于非编码RNA的异常表达及其在肿瘤发生和进展中的作用。已经证实，非编码RNA在转录和转录后水平发挥其调控功能，这导致了骨肉瘤的肿瘤发生或进展。根据目前的知识，本综述对微小RNA、长链非编码RNA和环状RNA在骨肉瘤中的功能和机制进行了最新概述。该综述还涵盖了它们在骨肉瘤诊断、预后和治疗方面的潜在临床应用。希望本综述中关于非编码RNA在骨肉瘤中的作用的信息能使人们对骨肉瘤有更全面的了解，并为非编码RNA在骨肉瘤患者潜在诊断和治疗应用方面提供有用的视角。
