Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
J Cell Biochem. 2023 Jun;124(6):785-796. doi: 10.1002/jcb.30425. Epub 2023 May 14.
Exosomes are membrane-surrounded extracellular vesicles released by almost all cell types, which mediate intercellular communications by delivering bioactive molecules from secretory cells to recipient cells. Long noncoding RNAs (lncRNAs) are a large class of non-(protein)-coding RNAs with lengths exceeding 200 nucleotides that are very active in the development of cardiovascular diseases (CVDs). Increasing evidence suggests that exosomal lncRNAs also play important roles in the progress of CVDs. We focus on the current available studies regarding these extracellular lncRNAs secreted and absorbed by cardiomyocytes and their functional roles in CVDs, hopefully providing a basis for deeper understanding of the pathological mechanisms of CVDs and their potential for clinical diagnosis and therapy.
外泌体是几乎所有细胞类型释放的具有膜包裹的细胞外囊泡，通过将生物活性分子从分泌细胞递送到受体细胞来介导细胞间通讯。长链非编码 RNA（lncRNA）是一类长度超过 200 个核苷酸的非常活跃的非（蛋白）编码 RNA，在心血管疾病（CVD）的发展中具有重要作用。越来越多的证据表明，外泌体 lncRNA 也在 CVD 的进展中发挥重要作用。我们关注目前关于心肌细胞分泌和吸收的这些细胞外 lncRNA 的可用研究及其在 CVD 中的功能作用，希望为深入了解 CVD 的病理机制及其在临床诊断和治疗中的潜力提供基础。
