Zolfaghari Dehkharghani Maryam, Mousavi Safa, Kianifard Nazanin, Fazlzadeh Amin, Parsa Hamid, Tavakoli Pirzaman Ali, Fazlollahpour-Naghibi Andarz
School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Cardiol Heart Vasc. 2024 Oct 17;55:101529. doi: 10.1016/j.ijcha.2024.101529. eCollection 2024 Dec.
Myocardial infarction (MI), a major global cause of mortality and morbidity, continues to pose a significant burden on public health. Despite advances in understanding its pathogenesis, there remains a need to elucidate the intricate molecular mechanisms underlying MI progression. Long non-coding RNAs (lncRNAs) have emerged as key regulators in diverse biological processes, yet their specific roles in MI pathophysiology remain elusive. Conducting a thorough review of literature using PubMed and Google Scholar databases, we investigated the involvement of lncRNAs in MI, focusing on their regulatory functions and downstream signaling pathways. Our analysis revealed extensive dysregulation of lncRNAs in MI, impacting various biological processes through diverse mechanisms. Notably, lncRNAs act as crucial modulators of gene expression and signaling cascades, functioning as decoys, regulators, and scaffolds. Furthermore, studies identified the multifaceted roles of lncRNAs in modulating inflammation, apoptosis, autophagy, necrosis, fibrosis, remodeling, and ischemia-reperfusion injury during MI progression. Recent research highlights the pivotal contribution of lncRNAs to MI pathogenesis, offering novel insights into potential therapeutic interventions. Moreover, the identification of circulating lncRNA signatures holds promise for the development of non-invasive diagnostic biomarkers. In summary, findings underscore the significance of lncRNAs in MI pathophysiology, emphasizing their potential as therapeutic targets and diagnostic tools for improved patient management and outcomes.
心肌梗死（MI）是全球死亡和发病的主要原因，持续给公共卫生带来重大负担。尽管在理解其发病机制方面取得了进展，但仍需要阐明MI进展背后复杂的分子机制。长链非编码RNA（lncRNAs）已成为多种生物过程中的关键调节因子，但其在MI病理生理学中的具体作用仍不清楚。我们使用PubMed和谷歌学术数据库对文献进行了全面回顾，研究了lncRNAs在MI中的作用，重点关注其调节功能和下游信号通路。我们的分析揭示了MI中lncRNAs的广泛失调，通过多种机制影响各种生物过程。值得注意的是，lncRNAs作为基因表达和信号级联的关键调节因子，发挥着诱饵、调节因子和支架的作用。此外，研究确定了lncRNAs在MI进展过程中调节炎症、凋亡、自噬、坏死、纤维化、重塑和缺血再灌注损伤的多方面作用。最近的研究强调了lncRNAs对MI发病机制的关键贡献，为潜在的治疗干预提供了新的见解。此外，循环lncRNA特征的鉴定为无创诊断生物标志物的开发带来了希望。总之，研究结果强调了lncRNAs在MI病理生理学中的重要性，强调了它们作为治疗靶点和诊断工具的潜力，以改善患者管理和预后。
