Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul08826, Republic of Korea.
Advanced Sensor Lab, Samsung Advanced Institute of Technology (SAIT), Samsung Electronics Co., Ltd., Suwon16678, Republic of Korea.
Br J Nutr. 2023 Dec 14;130(11):1993-2001. doi: 10.1017/S0007114523001058. Epub 2023 May 15.
Blood carotenoid concentration measurement is considered the gold standard for fruit and vegetable (F&V) intake estimation; however, this method is invasive and expensive. Recently, skin carotenoid status (SCS) measured by optical sensors has been evaluated as a promising parameter for F&V intake estimation. In this cross-sectional study, we aimed to validate the utility of resonance Raman spectroscopy (RRS)-assessed SCS as a biomarker of F&V intake in Korean adults. We used data from 108 participants aged 20-69 years who completed SCS measurements, blood collection and 3-d dietary recordings. Serum carotenoid concentrations were quantified using HPLC, and dietary carotenoid and F&V intakes were estimated via 3-d dietary records using a carotenoid database for common Korean foods. The correlations of the SCS with serum carotenoid concentrations, dietary carotenoid intake and F&V intake were examined to assess SCS validity. SCS was positively correlated with total serum carotenoid concentration ( = 0·52, 95 % CI = 0·36, 0·64, < 0·001), serum -carotene concentration ( = 0·60, 95 % CI = 0·47, 0·71, < 0·001), total carotenoid intake ( = 0·20, 95 % CI = 0·01, 0·37, = 0·04), -carotene intake ( = 0·30, 95 % CI = 0·11, 0·46, = 0·002) and F&V intake ( = 0·40, 95 % CI = 0·23, 0·55, < 0·001). These results suggest that SCS can be a valid biomarker of F&V intake in Korean adults.
血液类胡萝卜素浓度测量被认为是评估水果和蔬菜（F&V）摄入量的金标准；然而，这种方法具有侵入性且昂贵。最近，光学传感器测量的皮肤类胡萝卜素状态（SCS）已被评估为评估 F&V 摄入量的有前途的参数。在这项横断面研究中，我们旨在验证共振拉曼光谱（RRS）评估的 SCS 作为韩国成年人 F&V 摄入量生物标志物的效用。我们使用了 108 名年龄在 20-69 岁之间完成 SCS 测量、血液采集和 3 天饮食记录的参与者的数据。使用高效液相色谱法定量血清类胡萝卜素浓度，通过使用常见韩国食品的类胡萝卜素数据库的 3 天饮食记录来估计膳食类胡萝卜素和 F&V 的摄入量。检查 SCS 与血清类胡萝卜素浓度、膳食类胡萝卜素摄入量和 F&V 摄入量的相关性，以评估 SCS 的有效性。SCS 与总血清类胡萝卜素浓度呈正相关（ = 0·52，95 % CI = 0·36，0·64， < 0·001），与血清 -胡萝卜素浓度呈正相关（ = 0·60，95 % CI = 0·47，0·71， < 0·001），与总类胡萝卜素摄入量呈正相关（ = 0·20，95 % CI = 0·01，0·37， = 0·04），与 -胡萝卜素摄入量呈正相关（ = 0·30，95 % CI = 0·11，0·46， = 0·002），与 F&V 摄入量呈正相关（ = 0·40，95 % CI = 0·23，0·55， < 0·001）。这些结果表明，SCS 可以成为韩国成年人 F&V 摄入量的有效生物标志物。
