Department of Formulation Design and Pharmaceutical Technology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Department of Chemical, Energy, and Environmental Engineering, Faculty of Environmental and Urban Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan.
ACS Appl Bio Mater. 2023 Sep 18;6(9):3451-3462. doi: 10.1021/acsabm.3c00162. Epub 2023 May 15.
Metal-organic frameworks (MOFs) with versatile functionalities have applications in environmental science, sensor separation, catalysis, and drug delivery. In particular, MOFs used in drug delivery should be biodegradable and easy to control. In this study, spray-dried cyclodextrin-based MOFs (CD-MOFs) with tunable crystallinity, porosity, and dissolution properties were fabricated. The spray-drying precursor properties, such as ethanol volume ratio, incubation time, and precursor concentration, were optimized for controlled crystallization. On the basis of the morphology, X-ray diffraction peak intensity, and specific surface areas of the spray-dried CD-MOF products, they were categorized as amorphous, partially crystalline, and highly crystalline. An active pharmaceutical ingredient ketoconazole (KCZ) was introduced into the precursor to prepare KCZ-containing CD-MOFs. The surface areas of these products were greater by 3-fold (292 m/g) than that of the plain CD-MOF (94.1 m/g) prepared using the same parameters. The presence of KCZ in the hydrophobic cavity between the two γ-CD molecules was correlated to the CD-MOF crystal growth. Additionally, CD-MOF particles exhibited different dissolution behaviors on the basis of the position of KCZ in the MOF. These spray-dried CD-MOFs with tunable morphology, specific surface area, and dissolution could have potential applications in various fields.
具有多功能的金属-有机骨架（MOFs）在环境科学、传感器分离、催化和药物输送等领域有应用。特别是，用于药物输送的 MOFs 应该是可生物降解且易于控制的。在这项研究中，制备了喷雾干燥的具有可调结晶度、孔隙率和溶解性能的环糊精基 MOFs（CD-MOFs）。优化了喷雾干燥前体的性质，如乙醇体积比、孵育时间和前体浓度，以实现可控结晶。基于喷雾干燥 CD-MOF 产物的形态、X 射线衍射峰强度和比表面积，它们被归类为无定形、部分结晶和高结晶。将活性药物成分酮康唑（KCZ）引入前体中，制备含有 KCZ 的 CD-MOF。这些产物的比表面积比使用相同参数制备的普通 CD-MOF（94.1 m/g）大 3 倍（292 m/g）。KCZ 存在于两个γ-CD 分子之间的疏水性空腔中，与 CD-MOF 晶体生长有关。此外，根据 MOF 中 KCZ 的位置，CD-MOF 颗粒表现出不同的溶解行为。这些具有可调形态、比表面积和溶解性能的喷雾干燥 CD-MOF 可能在各个领域有潜在应用。
