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1
The molecular structure of a rapidly formed oligomeric adenosine tetraphosphate derivative from rat heart.来自大鼠心脏的快速形成的寡聚四磷酸腺苷衍生物的分子结构。
Biochem J. 1986 Mar 15;234(3):623-7. doi: 10.1042/bj2340623.
2
Evidence for the presence of oligophosphoglyceroyl-ATP in rat offney.大鼠肾中存在寡磷酸甘油酰 - ATP 的证据。
Biochem J. 1986 Dec 1;240(2):597-9. doi: 10.1042/bj2400597.
3
The discovery of a rapidly metabolized polymeric tetraphosphate derivative of adenosine in perfused rat heart.在灌注大鼠心脏中发现一种腺苷的快速代谢的聚合四磷酸盐衍生物。
Biochem J. 1984 Nov 1;223(3):627-32. doi: 10.1042/bj2230627.
4
The characterization of a new enzyme from rat liver mitochondria, oligophosphoglyceroyl-ATP 3'-phosphodiesterase.大鼠肝线粒体中新酶寡磷酸甘油酰 -ATP 3'-磷酸二酯酶的特性鉴定
Biochem J. 1991 Feb 15;274 ( Pt 1)(Pt 1):275-9. doi: 10.1042/bj2740275.
5
The mitochondrial phosphoglyceroyl-ATP-containing polymer, purinogen, is unchanged by cardiac ischaemia and reperfusion but may function in the regulation of free intracellular inorganic phosphate concentrations.线粒体中含磷酸甘油酰 - ATP的聚合物嘌呤原，在心脏缺血和再灌注过程中未发生变化，但可能在调节细胞内游离无机磷酸盐浓度方面发挥作用。
Eur J Biochem. 1998 May 15;254(1):75-80. doi: 10.1046/j.1432-1327.1998.2540075.x.
6
The control of cellular adenine nucleotides: the discovery and metabolism of an oligomeric derivative of ATP and phosphoglyceric acid in mitochondrial intermembrane space.细胞腺嘌呤核苷酸的调控：线粒体外膜间隙中ATP与磷酸甘油酸寡聚衍生物的发现与代谢
Adv Enzyme Regul. 1993;33:221-34. doi: 10.1016/0065-2571(93)90020-e.
7
In perfused rat hearts ischaemia promotes the reversible conversion of appreciable quantities of soluble adenine nucleotides to a stable trichloroacetic acid-precipitable form.在灌注的大鼠心脏中，缺血促使相当数量的可溶性腺嘌呤核苷酸可逆地转化为一种稳定的可被三氯乙酸沉淀的形式。
Biosci Rep. 1981 Nov;1(11):857-63. doi: 10.1007/BF01114819.
8
Evidence that the recently discovered high-energy nucleotide derivative, oligo(phosphoglyceroyl-ATP) forms the end chains of purinogen, a complex polymeric major storage form of adenine nucleotide and phosphate in heart.有证据表明，最近发现的高能核苷酸衍生物寡聚（磷酸甘油酰 - ATP）构成了嘌呤原的末端链，嘌呤原是心脏中腺嘌呤核苷酸和磷酸盐的一种复杂聚合主要储存形式。
Eur J Biochem. 1994 Mar 15;220(3):663-9. doi: 10.1111/j.1432-1033.1994.tb18667.x.
9
Studies on nucleotide analogs. I. Synthesis of two 9-alpha-D-mannofuranosyladenine phosphates, and their inhibition of adenylate kinase.核苷酸类似物的研究。I. 两种9-α-D-呋喃甘露糖基腺嘌呤磷酸酯的合成及其对腺苷酸激酶的抑制作用。
Carbohydr Res. 1973 Sep;30(1):133-42. doi: 10.1016/s0008-6215(00)82180-1.
10
2'5' oligoadenylate synthetase, an interferon induced enzyme: direct assay methods for the products, 2'5' oligoadenylates and 2'5' co-oligonucleotides.2',5'-寡腺苷酸合成酶，一种干扰素诱导酶：2',5'-寡腺苷酸和2',5'-共寡核苷酸产物的直接测定方法
Nucleic Acids Res. 1980 Jul 25;8(14):3073-85. doi: 10.1093/nar/8.14.3073.

引用本文的文献

1
Purinogen is not an endogenous substrate used in endothelial cells during substrate deprivation.嘌呤原不是内皮细胞在底物剥夺期间所使用的内源性底物。
Biochem J. 1999 Mar 1;338 ( Pt 2)(Pt 2):523-7.
2
Evidence for the presence of oligophosphoglyceroyl-ATP in rat offney.大鼠肾中存在寡磷酸甘油酰 - ATP 的证据。
Biochem J. 1986 Dec 1;240(2):597-9. doi: 10.1042/bj2400597.
3
Studies of adenosine incorporation in Langendorff rat heart and rat heart mitochondria.腺苷掺入兰根道夫大鼠心脏和大鼠心脏线粒体的研究。
Mol Cell Biochem. 1987 Nov;78(1):37-46. doi: 10.1007/BF00224422.
4
The role of glutamine oxidation and the purine nucleotide cycle for adaptation of tumour energetics to the transition from the anaerobic to the aerobic state.谷氨酰胺氧化和嘌呤核苷酸循环在肿瘤能量代谢适应从无氧状态向有氧状态转变中的作用。
Biochem J. 1988 Jun 1;252(2):381-6. doi: 10.1042/bj2520381.
5
The characterization of a new enzyme from rat liver mitochondria, oligophosphoglyceroyl-ATP 3'-phosphodiesterase.大鼠肝线粒体中新酶寡磷酸甘油酰 -ATP 3'-磷酸二酯酶的特性鉴定
Biochem J. 1991 Feb 15;274 ( Pt 1)(Pt 1):275-9. doi: 10.1042/bj2740275.

本文引用的文献

1
Studies on fetuin, a glycoprotein of fetal serum. I. Isolation, chemical composition, and physiochemical properties.关于胎球蛋白（一种胎儿血清糖蛋白）的研究。I. 分离、化学成分及理化性质。
J Biol Chem. 1960 Oct;235(10):2860-9.
2
Separation of the phosphoric esters on the filter paper chromatogram.磷酸酯在滤纸色谱上的分离
Nature. 1949 Dec 31;164(4183):1107-12, illust. doi: 10.1038/1641107a0.
3
Detection of sugars on paper chromatograms.纸色谱上糖的检测
Nature. 1950 Sep 9;166(4219):444-5. doi: 10.1038/166444b0.
4
In perfused rat hearts ischaemia promotes the reversible conversion of appreciable quantities of soluble adenine nucleotides to a stable trichloroacetic acid-precipitable form.在灌注的大鼠心脏中，缺血促使相当数量的可溶性腺嘌呤核苷酸可逆地转化为一种稳定的可被三氯乙酸沉淀的形式。
Biosci Rep. 1981 Nov;1(11):857-63. doi: 10.1007/BF01114819.
5
The discovery of a rapidly metabolized polymeric tetraphosphate derivative of adenosine in perfused rat heart.在灌注大鼠心脏中发现一种腺苷的快速代谢的聚合四磷酸盐衍生物。
Biochem J. 1984 Nov 1;223(3):627-32. doi: 10.1042/bj2230627.
6
Inversely related oscillations in the contents of cyclic GMP and the total adenine nucleotides in steady-state perfused rat hearts.
FEBS Lett. 1981 Aug 17;131(1):55-9. doi: 10.1016/0014-5793(81)80886-1.
7
Ion-exchange thin-layer chromatography. 13. Resolution of complex nucleoside triphosphate mixtures.离子交换薄层色谱法。13. 复杂核苷三磷酸混合物的分离。
Anal Biochem. 1965 Nov;13(2):211-22. doi: 10.1016/0003-2697(65)90191-0.
8
Quantitative thin-layer chromatography of ATP and the products of its degradation in meat tissue.肉类组织中ATP及其降解产物的定量薄层色谱分析。
J Chromatogr. 1974 Mar 13;90(1):105-11. doi: 10.1016/s0021-9673(01)94779-x.
9
A possible adenine nucleotide storage form in normal and ischaemic rat heart.正常和缺血大鼠心脏中一种可能的腺嘌呤核苷酸储存形式。
Biosci Rep. 1985 Jan;5(1):7-12. doi: 10.1007/BF01117435.
10
Evidence that the coupling of histone gene expression and DNA synthesis in HeLa S3 cells is not mediated at the transscriptional level.有证据表明，海拉S3细胞中组蛋白基因表达与DNA合成的偶联并非在转录水平介导。
Biochem Biophys Res Commun. 1977 Jul 11;77(1):245-52. doi: 10.1016/s0006-291x(77)80189-7.

来自大鼠心脏的快速形成的寡聚四磷酸腺苷衍生物的分子结构。

The molecular structure of a rapidly formed oligomeric adenosine tetraphosphate derivative from rat heart.

作者信息

Hutchinson W L, Morris P G, Mowbray J

出版信息

Biochem J. 1986 Mar 15;234(3):623-7. doi: 10.1042/bj2340623.

DOI:10.1042/bj2340623
PMID:3718488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1146617/
Abstract

The inability to account for large systematic variations with time in soluble adenine nucleotides in perfused rat hearts [Bates, Perrett & Mowbray (1978) Biochem. J. 176, 485-493; Mowbray, Bates & Perrett (1981) FEBS Lett. 131, 55-59; Mowbray, Perrett & Bates (1984) Int. J. Biochem. 16, 889-894] led us to show that the soluble nucleotides are in rapid equilibrium with some hitherto unrecognized trichloroacetic acid/methanol-precipitable highly phosphorylated heteropolymeric form [Mowbray, Hutchinson, Tibbs & Morris (1984) Biochem. J. 223, 627-632]. Selective digestion coupled to chromatographic analysis together with m.s. and 31P-n.m.r. spectrometry have now been used to show that the likely structure for a purified oligomer that is in specific-radioactivity equilibrium with tissue ATP is 3-phospho-[glyceroyl-gamma-triphosphoroyl-5'-adenosine-3'-3- phospho]4 glyceroyl-gamma-triphosphoroyl-5'-adenosine.

摘要

在灌注大鼠心脏中，可溶性腺嘌呤核苷酸随时间出现的较大系统性变化无法得到解释【贝茨、佩雷特和莫布雷（1978年）《生物化学杂志》第176卷，第485 - 493页；莫布雷、贝茨和佩雷特（1981年）《欧洲生物化学学会联合会快报》第131卷，第55 - 59页；莫布雷、佩雷特和贝茨（1984年）《国际生物化学杂志》第16卷，第889 - 894页】，这促使我们发现，可溶性核苷酸与某种迄今未被认识的三氯乙酸/甲醇可沉淀的高度磷酸化杂聚体形式处于快速平衡状态【莫布雷、哈钦森、蒂布斯和莫里斯（1984年）《生物化学杂志》第223卷，第627 - 632页】。现在，结合色谱分析的选择性消化以及质谱和³¹P - 核磁共振光谱已被用于表明，与组织ATP处于比放射性平衡的纯化寡聚体的可能结构是3 - 磷酸 - [甘油酰 - γ - 三磷酸酰基 - 5'-腺苷 - 3'-3 - 磷酸]4甘油酰 - γ - 三磷酸酰基 - 5'-腺苷。