最佳状态评分工具：指导严重支气管肺发育不良婴儿的跨学科护理及其与线性生长的关系。
The Optimal State Scoring Tool: guidance for interdisciplinary care of infants with severe bronchopulmonary dysplasia and its relation to linear growth.
机构信息
Department of Clinical Nutrition & Lactation, Nationwide Children's Hospital, Columbus, OH, USA.
Department of Neonatology, Phoenix Children's Hospital, Phoenix, AZ, USA.
出版信息
J Perinatol. 2023 Oct;43(10):1301-1307. doi: 10.1038/s41372-023-01680-x. Epub 2023 Apr 25.
OBJECTIVE
Infants with severe bronchopulmonary dysplasia (sBPD) have complex medical courses. We developed the clinician-rated Optimal State Scoring Tool (OSST) that measures factors relevant to clinical improvement of sBPD and investigated preliminary validity using linear growth outcome and OSST scores in sBPD patients.
METHODS
Tool development process and pilot findings are provided for 13 patients evaluated longitudinally. OSST scores, length measurements, and steroid dependency values were obtained. Changes in OSST scores and lengths were examined using linear mixed-effect models.
RESULTS
OSST scores were significantly correlated with linear growth (95% CI 0.36, 0.57). The steroid-dependent group showed significantly slower rate of linear growth (95% CI 0.74, 1.05) and slower rate of increase in OSST scores (95% CI 0.99, 2.13) compared to the non-steroid-dependent group, with the OSST showing the largest effect size.
CONCLUSION
Pilot data reflect promising evidence for OSST construct validity in monitoring clinical outcomes in sBPD patients.
目的
患有严重支气管肺发育不良（sBPD）的婴儿具有复杂的医疗过程。我们开发了临床医生评分的最佳状态评分工具（OSST），该工具可衡量与 sBPD 临床改善相关的因素，并使用 sBPD 患者的线性生长结果和 OSST 评分研究了初步有效性。
方法
提供了用于对 13 名患者进行纵向评估的工具开发过程和初步发现。获得了 OSST 评分、长度测量值和类固醇依赖性值。使用线性混合效应模型检查了 OSST 评分和长度的变化。
结果
OSST 评分与线性生长呈显著相关（95%CI 0.36,0.57）。与非类固醇依赖组相比，类固醇依赖组的线性生长速度明显较慢（95%CI 0.74,1.05），OSST 评分的增长速度也较慢（95%CI 0.99,2.13），OSST 的效果量最大。
结论
初步数据反映了 OSST 在监测 sBPD 患者临床结局方面具有良好的结构有效性的有希望的证据。
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