极早产儿线性生长受限的神经发育结局。
Neurodevelopmental outcomes among extremely premature infants with linear growth restriction.
机构信息
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC, USA.
出版信息
J Perinatol. 2019 Feb;39(2):193-202. doi: 10.1038/s41372-018-0259-8. Epub 2018 Oct 23.
OBJECTIVE
To compare neurodevelopmental outcomes in linear growth-restricted (LGR) infants born <29 weeks with and without weight gain out of proportion to linear growth.
STUDY DESIGN
We compared 2-year neurodevelopmental outcomes between infants with and without LGR and between LGR infants with and without weight gain out of proportion to linear growth. The outcomes were Bayley-III cognitive, motor, and language scores, cerebral palsy, Gross Motor Function Classification System (GMFCS) level ≥ 2, and neurodevelopmental impairment.
RESULT
In total, 1227 infants were analyzed. LGR infants were smaller and less mature at birth, had higher BMI, and had lower Bayley-III language scores (82.3 vs. 85.0, p < 0.05). Among infants with LGR, infants with high BMI had lower language scores compared with those with low-to-normal BMI (80.8 vs. 83.3, p < 0.05), and were more likely to have GMFCS level ≥2 and neurodevelopmental impairment.
CONCLUSION
Among infants with LGR, weight gain out of proportion to linear growth was associated with poorer neurodevelopmental outcomes.
目的
比较<29 周出生的线性生长受限（LGR）婴儿中，与线性生长不成比例的体重增加和无体重增加的神经发育结局。
研究设计
我们比较了有和无 LGR 以及有和无与线性生长不成比例的体重增加的 LGR 婴儿的 2 年神经发育结局。结局是贝利 III 认知、运动和语言评分、脑瘫、粗大运动功能分类系统（GMFCS）水平≥2 和神经发育障碍。
结果
共分析了 1227 名婴儿。LGR 婴儿出生时更小、更不成熟，体重指数更高，且贝利 III 语言评分更低（82.3 比 85.0，p<0.05）。在 LGR 婴儿中，高体重指数的婴儿语言评分低于低至正常体重指数的婴儿（80.8 比 83.3，p<0.05），且更有可能出现 GMFCS 水平≥2 和神经发育障碍。
结论
在 LGR 婴儿中，与线性生长不成比例的体重增加与较差的神经发育结局相关。
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