Behrooz Leili, Abumoawad Abdelrhman, Rizvi Syed Husain M, Hamburg Naomi M
Whitaker Cardiovascular Institute, Boston University Chobanian and Avedisian School of Medicine, Section of Vascular Biology, Boston Medical Center, Boston, MA, United States.
Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.
Front Cardiovasc Med. 2023 Apr 28;10:1154708. doi: 10.3389/fcvm.2023.1154708. eCollection 2023.
Peripheral artery disease (PAD) is associated with increased risk of cardiovascular morbidity and mortality, poor functional status, and lower quality of life. Cigarette smoking is a major preventable risk factor for PAD and is strongly associated with a higher risk of disease progression, worse post-procedural outcomes, and increased healthcare utilization. The arterial narrowing due to atherosclerotic lesions in PAD leads to decreased perfusion to the limbs and can ultimately cause arterial obstruction and limb ischemia. Endothelial cell dysfunction, oxidative stress, inflammation, and arterial stiffness are among the key events during the development of atherogenesis. In this review, we discuss the benefits of smoking cessation among patients with PAD and the use of smoking cessation methods including pharmacological treatment. Given that smoking cessation interventions remain underutilized, we highlight the importance of incorporating smoking cessation treatments as part of the medical management of patients with PAD. Regulatory approaches to reduce the uptake of tobacco product use and support smoking cessation have the potential to reduce the burden of PAD.
外周动脉疾病（PAD）与心血管疾病发病率和死亡率增加、功能状态不佳及生活质量降低相关。吸烟是PAD的主要可预防风险因素，与疾病进展风险更高、术后预后更差及医疗保健利用率增加密切相关。PAD中动脉粥样硬化病变导致的动脉狭窄会使肢体灌注减少，并最终导致动脉阻塞和肢体缺血。内皮细胞功能障碍、氧化应激、炎症和动脉僵硬度是动脉粥样硬化发生过程中的关键事件。在本综述中，我们讨论了PAD患者戒烟的益处以及包括药物治疗在内的戒烟方法的应用。鉴于戒烟干预措施的使用仍未得到充分利用，我们强调将戒烟治疗纳入PAD患者医疗管理的重要性。减少烟草制品使用和支持戒烟的监管方法有可能减轻PAD的负担。
