咪康唑可延长小鼠皮肤移植的存活时间。
Miconazole prolongs murine skin graft survival.
作者信息
Thong Y H, Ferrante A
出版信息
Clin Exp Immunol. 1979 Jan;35(1):10-2.
Abstract
The effects of miconazole, a broad spectrum anti-fungal compound, on the immune response was studied in mice. At the non-toxic dose of 300 mg/kg per day, there was minimal suppression of the antibody response to sheep red blood cells. In contrast, there was a marked prolongation of skin graft survival from 13.6 +/- 1.8 days (mean +/- s.d.) in untreated mice to 18.6 +/- 3.5 dyas in the treated group. Miconazole may be of use in clinical transplantation.
摘要
研究了广谱抗真菌化合物咪康唑对小鼠免疫反应的影响。在每天300毫克/千克的无毒剂量下，对绵羊红细胞的抗体反应仅有轻微抑制。相比之下，皮肤移植存活时间显著延长，从未治疗小鼠的13.6±1.8天（平均值±标准差）延长至治疗组的18.6±3.5天。咪康唑可能在临床移植中有用。
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本文引用的文献
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The use of antigenic tissue extracts to weaken the immunological reaction against skin homografts in mice.使用抗原性组织提取物来减弱小鼠对皮肤同种异体移植的免疫反应。
Transplantation. 1963 Jan;1:21-38. doi: 10.1097/00007890-196301010-00004.
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Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response.小鼠异种抗淋巴细胞血清的研究。II. 对免疫反应的影响。
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Miconazole, a broad-spectrum antimycotic agent with antibacterial activity.咪康唑，一种具有抗菌活性的广谱抗真菌剂。
Chemotherapy. 1972;17(6):392-404. doi: 10.1159/000220875.
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