咪康唑可延长小鼠皮肤移植的存活时间。
Miconazole prolongs murine skin graft survival.
作者信息
Thong Y H, Ferrante A
出版信息
Clin Exp Immunol. 1979 Jan;35(1):10-2.
Abstract
The effects of miconazole, a broad spectrum anti-fungal compound, on the immune response was studied in mice. At the non-toxic dose of 300 mg/kg per day, there was minimal suppression of the antibody response to sheep red blood cells. In contrast, there was a marked prolongation of skin graft survival from 13.6 +/- 1.8 days (mean +/- s.d.) in untreated mice to 18.6 +/- 3.5 dyas in the treated group. Miconazole may be of use in clinical transplantation.
摘要
研究了广谱抗真菌化合物咪康唑对小鼠免疫反应的影响。在每天300毫克/千克的无毒剂量下，对绵羊红细胞的抗体反应仅有轻微抑制。相比之下，皮肤移植存活时间显著延长，从未治疗小鼠的13.6±1.8天（平均值±标准差）延长至治疗组的18.6±3.5天。咪康唑可能在临床移植中有用。
相似文献
1
Miconazole prolongs murine skin graft survival.
Clin Exp Immunol. 1979 Jan;35(1):10-2.
2
The effect of ampicillin on skin graft survival and antibody response in B6A F1 mice.
Arch Immunol Ther Exp (Warsz). 1981;29(3):379-83.
3
FTY720 treatment prolongs skin graft survival in a completely incompatible strain combination.
Transplant Proc. 2004 May;36(4):1015-7. doi: 10.1016/j.transproceed.2004.03.052.
4
The novel IMPDH inhibitor VX-497 prolongs skin graft survival and improves graft versus host disease in mice.
Drugs Exp Clin Res. 2001;27(3):89-95.
5
The effect of penicillin on skin graft survival in mice.
Arch Immunol Ther Exp (Warsz). 1984;32(3):351-6.
6
Both L- and D-isomers of allotrap 2702 prolong cardiac allograft survival in mice.
J Heart Lung Transplant. 1996 Jan;15(1 Pt 1):78-87.
7
A combination of anergic cells' adoptive transfer and rapamycin therapy prolongs cardiac allograft survival in mice.
Scand J Immunol. 2005 Mar;61(3):266-73. doi: 10.1111/j.1365-3083.2005.01555.x.
8
In vivo treatment of mice with heat shock protein, gp 96, improves survival of skin grafts with minor and major antigenic disparity.
Transpl Immunol. 2006 Jan;15(3):179-85. doi: 10.1016/j.trim.2005.07.003. Epub 2005 Aug 9.
9
[Prolonging transplant survival time by PUVA treatment of the transplant recipient. Significance of cis-urocanic acid].
Dermatol Monatsschr. 1990;176(1):49-54.
10
Long-term limb allograft survival using anti-CD40L antibody in a murine model.
Transplantation. 2003 Mar 15;75(5):644-50. doi: 10.1097/01.TP.0000053756.90975.8E.
引用本文的文献
1
Immunopotentiation by pyrimethamine in the mouse.
Clin Exp Immunol. 1980 Jan;39(1):190-4.
本文引用的文献
1
The use of antigenic tissue extracts to weaken the immunological reaction against skin homografts in mice.
Transplantation. 1963 Jan;1:21-38. doi: 10.1097/00007890-196301010-00004.
2
Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response.
J Immunol. 1966 Feb;96(2):229-38.
3
The effects of heterologous anti-thymocyte sera in mice. I. The use of a graft-vs.-host assay as a measure of homograft reactivity.
J Immunol. 1968 Jun;100(6):1319-25.
4
Miconazole, a broad-spectrum antimycotic agent with antibacterial activity.
Chemotherapy. 1972;17(6):392-404. doi: 10.1159/000220875.
5
Miconazole therapy for coccidioidomycosis.
JAMA. 1974 Nov 25;230(8):1153-7.
6
Niridazole. II. A potent long-acting suppressant of cellular hypersensitivity.
J Immunol. 1975 Jan;114(1 Pt 2):279-83.
7
Miconazole in coccidiodomycosis. II. Therapeutic and pharmacologic studies in man.
Am J Med. 1976 Feb;60(2):191-202. doi: 10.1016/0002-9343(76)90428-9.
8
Inhibitory effect of miconazole on mitogen-induced lymphocyte proliferative responses.
Br Med J. 1978 Jan 21;1(6106):149. doi: 10.1136/bmj.1.6106.149.
9
Suppression of cell-mediated immunity by metronidazole.
Int Arch Allergy Appl Immunol. 1977;54(5):422-7. doi: 10.1159/000231857.
Zotero 插件