Thong Y H, Ferrante A
Clin Exp Immunol. 1979 Jan;35(1):10-2.
The effects of miconazole, a broad spectrum anti-fungal compound, on the immune response was studied in mice. At the non-toxic dose of 300 mg/kg per day, there was minimal suppression of the antibody response to sheep red blood cells. In contrast, there was a marked prolongation of skin graft survival from 13.6 +/- 1.8 days (mean +/- s.d.) in untreated mice to 18.6 +/- 3.5 dyas in the treated group. Miconazole may be of use in clinical transplantation.
研究了广谱抗真菌化合物咪康唑对小鼠免疫反应的影响。在每天300毫克/千克的无毒剂量下，对绵羊红细胞的抗体反应仅有轻微抑制。相比之下，皮肤移植存活时间显著延长，从未治疗小鼠的13.6±1.8天（平均值±标准差）延长至治疗组的18.6±3.5天。咪康唑可能在临床移植中有用。
