乙胺嘧啶对小鼠的免疫增强作用。
Immunopotentiation by pyrimethamine in the mouse.
作者信息
Thong Y H, Ferrante A
出版信息
Clin Exp Immunol. 1980 Jan;39(1):190-4.
Abstract
Pyrimethamine, a 2,4-diaminopyrimidine useful in the treatment of malaria and toxoplasmosis, was found to enhance antibody and delayed-type hypersensitivity responses to sheep red cells in mice. The immunodepression of tumour-bearing mice was also reversed by pyrimethamine. This drug may prove useful as a general immunostimulant in clinical situations where the immune system has been compromised by cancer or other debilitating illnesses.
摘要
乙胺嘧啶是一种可用于治疗疟疾和弓形虫病的2,4-二氨基嘧啶，它能增强小鼠对绵羊红细胞的抗体反应和迟发型超敏反应。乙胺嘧啶还能逆转荷瘤小鼠的免疫抑制状态。在免疫系统因癌症或其他使人虚弱的疾病而受损的临床情况下，这种药物可能被证明是一种有用的通用免疫刺激剂。
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引用本文的文献
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本文引用的文献
1
2:4-diaminopyrimidines- a new series of antimalarials.2,4-二氨基嘧啶——一类新型抗疟药。
Br J Pharmacol Chemother. 1951 Jun;6(2):185-200. doi: 10.1111/j.1476-5381.1951.tb00634.x.
2
Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity.两名细胞免疫严重受损患者的腺苷脱氨酶缺乏症。
Lancet. 1972 Nov 18;2(7786):1067-9. doi: 10.1016/s0140-6736(72)92345-8.
3
The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity.啮齿动物疟疾的化学疗法，XXII. 伯氏疟原虫耐药株在筛选血内裂殖体杀灭活性中的价值。
Ann Trop Med Parasitol. 1975 Jun;69(2):155-71.
4
Primaquine inhibits mitogen-induced human lymphocyte proliferative responses.伯氨喹抑制有丝分裂原诱导的人淋巴细胞增殖反应。
Trans R Soc Trop Med Hyg. 1978;72(5):537-9. doi: 10.1016/0035-9203(78)90181-5.
5
Suppression of immunological responses in mice by treatment with amphotericin B.两性霉素B治疗对小鼠免疫反应的抑制作用。
Clin Exp Immunol. 1979 Oct;38(1):70-6.
6
Inhibition of mitogen-induced human lymphocyte proliferative responses by tetracycline analogues.四环素类似物对丝裂原诱导的人淋巴细胞增殖反应的抑制作用。
Clin Exp Immunol. 1979 Mar;35(3):443-6.
7
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Lancet. 1975 May 3;1(7914):1010-3. doi: 10.1016/s0140-6736(75)91950-9.
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