Thong Y H, Ferrante A
Clin Exp Immunol. 1980 Jan;39(1):190-4.
Pyrimethamine, a 2,4-diaminopyrimidine useful in the treatment of malaria and toxoplasmosis, was found to enhance antibody and delayed-type hypersensitivity responses to sheep red cells in mice. The immunodepression of tumour-bearing mice was also reversed by pyrimethamine. This drug may prove useful as a general immunostimulant in clinical situations where the immune system has been compromised by cancer or other debilitating illnesses.
乙胺嘧啶是一种可用于治疗疟疾和弓形虫病的2,4-二氨基嘧啶,它能增强小鼠对绵羊红细胞的抗体反应和迟发型超敏反应。乙胺嘧啶还能逆转荷瘤小鼠的免疫抑制状态。在免疫系统因癌症或其他使人虚弱的疾病而受损的临床情况下,这种药物可能被证明是一种有用的通用免疫刺激剂。