Sakamoto N, Ohtomo H, Kogure K
No To Shinkei. 1986 Apr;38(4):387-91.
Indeloxazine hydrochloride (Indeloxazine) has been known as a new type drug with enhancing effects on memory and learning processes in various experimental models. In the present studies, effects of Indeloxazine on brain energy and glucose metabolisms were determined in four-vessel occlusion rat model. Since a critical point of ischemic time for the recovery of brain energy levels existed between 30 min and 60 min in this model, effects of Indeloxazine were determined in the rat model of 60 min recirculation following 60 min ischemia. One-week dosing of Indeloxazine at 2 mg/kg showed slight increases in ATP and total adenine nucleotides levels. To elucidate the mechanism of improving action of Indeloxazine on brain energy levels, effects on glucose metabolism were determined. Non-treated group of 60 min ischemia-60 min recirculation showed severe reduction of 14C-2-deoxyglucose metabolism in comparison to normal control group. Indeloxazine-treated group showed a slight improvement of 14C-2-deoxyglucose metabolism in comparison to non-treated group. Furthermore, high 14C-2-deoxyglucose metabolism was observed in parts of hippocampus, cortex and thalamus. From these results, it seems possible that Indeloxazine has some protective effects on brain damage in four-vessel occlusion rat model.
盐酸茚达雷司（茚达雷司）在各种实验模型中作为一种对记忆和学习过程具有增强作用的新型药物已为人所知。在本研究中，在四动脉闭塞大鼠模型中测定了茚达雷司对脑能量和葡萄糖代谢的影响。由于在该模型中脑能量水平恢复的缺血时间关键点存在于30分钟至60分钟之间，因此在缺血60分钟后再灌注60分钟的大鼠模型中测定了茚达雷司的作用。以2mg/kg的剂量给茚达雷司给药一周后，ATP和总腺嘌呤核苷酸水平略有升高。为了阐明茚达雷司对脑能量水平改善作用的机制，测定了其对葡萄糖代谢的影响。与正常对照组相比，60分钟缺血-60分钟再灌注的未治疗组显示14C-2-脱氧葡萄糖代谢严重降低。与未治疗组相比，茚达雷司治疗组的14C-2-脱氧葡萄糖代谢略有改善。此外，在海马、皮质和丘脑的部分区域观察到高14C-2-脱氧葡萄糖代谢。从这些结果来看，茚达雷司在四动脉闭塞大鼠模型中似乎对脑损伤具有一定的保护作用。
