Stefanovich V
Z Gerontol. 1985 Jul-Aug;18(4):210-5.
In this review of brain energy metabolism, the utilization of glucose as the sole energy source in the normal brain is described and presented in a schematic form. Important reactions concerned with the synthesis and degradation of the energy carrier in the cell, ATP, are also noted. Changes in energy metabolism with acute oxygen deficiency are shown in the example of rat brain energy metabolism during 30 seconds of nitrogen breathing (significant decrease of phosphocreatine, ATP, total adenine nucleotides and adenylate energy charge). Several important metabolic changes, particularly in ion and lipid metabolism during the decrease in the cerebral blood flow (ischemia), are described in some detail and presented in schematic form. A short description of the [14C]-2-deoxyglucose method developed by L. Sokoloff for the determination of local cerebral utilization of glucose is followed by a description of the application of this method in the study of aging in rats.
在这篇关于脑能量代谢的综述中，正常大脑中葡萄糖作为唯一能量来源的利用情况以示意图的形式进行了描述和呈现。还提到了与细胞能量载体ATP的合成和降解相关的重要反应。以大鼠在呼吸氮气30秒期间脑能量代谢为例，展示了急性缺氧时能量代谢的变化（磷酸肌酸、ATP、总腺嘌呤核苷酸和腺苷酸能量电荷显著降低）。详细描述了几种重要的代谢变化，特别是脑血流量减少（缺血）期间离子和脂质代谢的变化，并以示意图的形式呈现。随后简要介绍了L.索科洛夫开发的用于测定局部脑葡萄糖利用的[14C]-2-脱氧葡萄糖法，接着描述了该方法在大鼠衰老研究中的应用。
