Agache Ioana, Laculiceanu Alexandru, Spanu Daniela, Grigorescu Dan
Faculty of Medicine, Transylvania University, Brasov, Romania.
Allergy Asthma Immunol Res. 2023 May;15(3):290-302. doi: 10.4168/aair.2023.15.3.290.
The worldwide prevalence of allergic disease is rising as a result of complex gene-environment interactions that shape the immune system and host response. Climate change and loss of biodiversity are existential threats to humans, animals, plants, and ecosystems. While there is significant progress in the development of targeted therapeutic options to treat allergies and asthma, these approaches are inadequate to meet the challenges faced by climate change. The exposomic approach is needed with the recognition of the bidirectional effect between human beings and the environment. All stakeholders need to work together toward mitigating the effects of climate change and promoting a One Health concept in order to decrease the burden of asthma and allergy and to improve immune health. Healthcare professionals should strive to incorporate One Health counseling, environmental health precepts, and advocacy into their practice.
由于塑造免疫系统和宿主反应的复杂基因-环境相互作用，过敏性疾病在全球的患病率正在上升。气候变化和生物多样性丧失对人类、动物、植物和生态系统构成了生存威胁。虽然在开发治疗过敏和哮喘的靶向治疗方案方面取得了重大进展，但这些方法不足以应对气候变化带来的挑战。鉴于认识到人类与环境之间的双向影响，需要采用暴露组学方法。所有利益相关者需要共同努力减轻气候变化的影响，推广“同一健康”概念，以减轻哮喘和过敏的负担并改善免疫健康。医疗保健专业人员应努力将“同一健康”咨询、环境卫生原则和宣传纳入其实践。
