Herdea Valeria, Tarciuc Petruta, Ghionaru Raluca, Pana Bogdan, Chirila Sergiu, Varga Andreea, Mărginean Cristina Oana, Diaconescu Smaranda, Leibovitz Eugene
Pharmacy, Science, and Technology of Targu Mures, George Emil Palade University of Medicine, 540142 Targu Mures, Romania.
Romanian Association for Pediatric Education in Family Medicine, 021507 Bucharest, Romania.
Children (Basel). 2023 Mar 29;10(4):640. doi: 10.3390/children10040640.
(1) Background: Immunization of pregnant women (PWs) against Bordetella pertussis infection is still a challenging health matter. (2) Methods: We gathered questionnaire data from 180 PWs regarding their expectancies and current opinion on infectious disease prevention. For the group of PWs who agreed to further investigations, the serum levels of Ig G anti-B. pertussis antibodies (IgG-PT) titer were measured and analyzed. (3) Results: A total of 180 PWs completed the questionnaire and 98 (54.44%, study group) accepted to perform the laboratory tests. During the first two pregnancy trimesters, PWs were found to be more willing (compared with the control group) to test for identifying high-risk situations that could affect themselves and their future infant ( < 0.001). Most of the participating PWs (91, 91.9%) had low levels of anti-pertussis antibodies (values < 40 IU/mL). Declared vaccine coverage of the PWs newborn infants for DTaP-1 and Prevenar 13 (at 2 months) and DTaP-2 and Prevenar 13 (at 4 months) vaccination reached 100% in the study group, while in the control group only 30/82 (36.59%) PWs accepted to be vaccinated during pregnancy, none of them providing data on their infants' vaccine coverage. (4) Conclusions: Enrolled PWs faced a waning immunity against the B. pertussis infection. By raising maternal confidence in the protective role of vaccines against infectious diseases, better vaccine acceptance and better infant vaccine coverage can be achieved.
(1) 背景：孕妇针对百日咳博德特氏菌感染进行免疫接种仍是一个具有挑战性的健康问题。(2) 方法：我们收集了180名孕妇关于其对传染病预防的期望和当前看法的问卷数据。对于同意进一步调查的孕妇组，测量并分析了血清中抗百日咳博德特氏菌抗体（IgG-PT）滴度水平。(3) 结果：共有180名孕妇完成了问卷，其中98名（54.44%，研究组）同意进行实验室检测。在前两个孕期，发现孕妇（与对照组相比）更愿意进行检测以识别可能影响自身及其未来婴儿的高危情况（<0.001）。大多数参与调查的孕妇（91名，91.9%）抗百日咳抗体水平较低（值<40 IU/mL）。研究组中，孕妇新生儿的白喉破伤风无细胞百日咳疫苗-1和13价肺炎球菌结合疫苗（2月龄时）以及白喉破伤风无细胞百日咳疫苗-2和13价肺炎球菌结合疫苗（4月龄时）的宣称疫苗接种覆盖率达到100%，而在对照组中，只有30/82（36.59%）的孕妇在孕期接受了疫苗接种，且她们均未提供其婴儿疫苗接种覆盖率的数据。(4) 结论：纳入研究的孕妇对百日咳博德特氏菌感染的免疫力正在下降。通过增强孕妇对疫苗预防传染病保护作用的信心，可以实现更好的疫苗接受度和更高的婴儿疫苗接种覆盖率。
