Makni Emna, Hachana Younes, Elloumi Mohamed
Laboratory of Physiology and Physiopathology, Faculty of Medicine Ibn El Jazzar, University of Sousse, Sousse 4000, Tunisia.
Preparatory Year Program, Dar Al Uloom University, Riyadh 13314, Saudi Arabia.
Children (Basel). 2023 Mar 30;10(4):658. doi: 10.3390/children10040658.
The 6-min walk test (6MWT) provides information regarding functional capacity, response to therapy and prognosis in a variety of chronic cardiovascular disorders. Variability in body size and composition, particularly in obese people, confounds the six-minute covered distance (6MWD). The aim of the present study was to adopt allometric models to identify the most appropriate body size/shape; i.e., body mass (BM), body height (BH), body mass index (BMI) and estimated fat-free mass (FFM); associated with the 6MWD in 190 young girls with obesity.
Nonlinear allometric modeling was used to calculate common body size exponents for BM, BH, BMI and FFM. In a validation sample of 35 age-matched obese girls, these allometric exponents were used prospectively.
The point estimates for the size exponents (95% confidence interval) from the separate allometric models were: BM 0.23 (0.19-0.27), BH 0.91 (0.78-1.03), BMI 0.33 (0.23-0.44) and FFM 0.28 (0.24-0.33). The presence of significant residual size correlations for 6MWD/BH indicates that the influence of body size was not correctly partitioned out. In the validation group, the correlations between 6MWD BM and BM, 6MWD BMI and BMI, and 6MWD FFM and FFM using the established exponents were not statistically different from zero (r = 0.01), implying that participants in the allometric investigation were not penalized based on their BM, BMI, or FFM.
We conclude that BM, BMI, BH and FFM, as indicators of body size/shape, are the most valid allometric denominators for the scaling of 6MWD in a group of young girls with obesity.
6分钟步行试验（6MWT）可提供有关各种慢性心血管疾病的功能能力、治疗反应和预后的信息。身体大小和组成的变异性，尤其是在肥胖人群中，会混淆6分钟步行距离（6MWD）。本研究的目的是采用异速生长模型来确定最合适的身体大小/形状，即体重（BM）、身高（BH）、体重指数（BMI）和估计去脂体重（FFM），并将其与190名肥胖年轻女孩的6MWD相关联。
使用非线性异速生长模型来计算BM、BH、BMI和FFM的常见身体大小指数。在35名年龄匹配的肥胖女孩的验证样本中，前瞻性地使用这些异速生长指数。
来自单独异速生长模型的大小指数的点估计值（95%置信区间）为：BM 0.23（0.19 - 0.27），BH 0.91（0.78 - 1.03），BMI 0.33（0.23 - 0.44）和FFM 0.28（0.24 - 0.33）。6MWD/BH存在显著的残余大小相关性，表明身体大小的影响没有被正确分离出来。在验证组中，使用既定指数的6MWD BM与BM、6MWD BMI与BMI以及6MWD FFM与FFM之间的相关性与零无统计学差异（r = 0.01），这意味着异速生长研究中的参与者不会因其BM、BMI或FFM而受到影响。
我们得出结论，BM、BMI、BH和FFM作为身体大小/形状的指标，是一组肥胖年轻女孩中6MWD缩放最有效的异速生长分母。
