Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 St. Petersburg, Russia.
Cells. 2023 Apr 14;12(8):1157. doi: 10.3390/cells12081157.
cAMP is a key regulatory molecule that controls many important processes in the retina, including phototransduction, cell development and death, growth of neural processes, intercellular contacts, retinomotor effects, and so forth. The total content of cAMP changes in the retina in a circadian manner following the natural light cycle, but it also shows local and even divergent changes in faster time scales in response to local and transient changes in the light environment. Changes in cAMP might also manifest or cause various pathological processes in virtually all cellular components of the retina. Here we review the current state of knowledge and understanding of the regulatory mechanisms by which cAMP influences the physiological processes that occur in various retinal cells.
环磷酸腺苷（cAMP）是一种关键的调节分子，可控制视网膜中的许多重要过程，包括光传导、细胞发育和死亡、神经过程的生长、细胞间接触、视网膜运动效应等。在遵循自然光照周期的情况下，cAMP 的总量会呈现出昼夜节律性变化，但它也会在更短的时间内对局部和瞬态的光环境变化做出局部甚至发散性的变化。cAMP 的变化也可能在视网膜的几乎所有细胞成分中表现出或导致各种病理过程。在这里，我们综述了 cAMP 影响各种视网膜细胞中生理过程的调节机制的现有知识和理解。
