Faculty of General Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Faculty of General Medicine, Ovidius University, 900470 Constanta, Romania.
Cells. 2023 Apr 14;12(8):1158. doi: 10.3390/cells12081158.
Heart failure is a worldwide health problem with important consequences for the overall wellbeing of affected individuals as well as for the healthcare system. Over recent decades, numerous pieces of evidence have demonstrated that the associated gut microbiota represent an important component of human physiology and metabolic homeostasis, and can affect one's state of health or disease directly, or through their derived metabolites. The recent advances in human microbiome studies shed light on the relationship between the gut microbiota and the cardiovascular system, revealing its contribution to the development of heart failure-associated dysbiosis. HF has been linked to gut dysbiosis, low bacterial diversity, intestinal overgrowth of potentially pathogenic bacteria and a decrease in short chain fatty acids-producing bacteria. An increased intestinal permeability allowing microbial translocation and the passage of bacterial-derived metabolites into the bloodstream is associated with HF progression. A more insightful understanding of the interactions between the human gut microbiome, HF and the associated risk factors is mandatory for optimizing therapeutic strategies based on microbiota modulation and offering individualized treatment. The purpose of this review is to summarize the available data regarding the influence of gut bacterial communities and their derived metabolites on HF, in order to obtain a better understanding of this multi-layered complex relationship.
心力衰竭是一个全球性的健康问题，对患者的整体健康以及医疗保健系统都有重要影响。近几十年来，大量证据表明，相关的肠道微生物群是人体生理学和代谢稳态的一个重要组成部分，它们可以直接或通过其衍生代谢物影响一个人的健康或疾病状态。人类微生物组研究的最新进展揭示了肠道微生物群与心血管系统之间的关系，揭示了其在心力衰竭相关的生态失调发展中的作用。心力衰竭与肠道生态失调、细菌多样性降低、潜在致病性细菌的肠道过度生长以及产生短链脂肪酸的细菌减少有关。肠道通透性增加允许微生物易位和细菌衍生代谢物进入血液与心力衰竭的进展相关。更深入地了解人类肠道微生物组、心力衰竭和相关危险因素之间的相互作用，对于基于微生物组调节优化治疗策略和提供个体化治疗是必要的。本综述的目的是总结关于肠道细菌群落及其衍生代谢物对心力衰竭影响的现有数据，以更好地理解这种多层次的复杂关系。
