Fadhillah Farhan S, Habibah Kona'atul, Juniarto Achmad Z, Sobirin Mochamad A, Maharani Nani, Pramono Adriyan
Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
Department of Medical Study, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
Asia Pac J Clin Nutr. 2025 Apr;34(2):141-152. doi: 10.6133/apjcn.202504_34(2).0001.
Chronic Heart Failure (CHF) is one of the leading cardiovascular diseases (CVDs), particularly in the Asian population. Individuals with specific health risks, such as obesity, type 2 diabetes, hypertension, dyslipidemia, and coronary artery disease (CAD), are more susceptible to developing CHF. Current evidence is limited to understanding the link between gut microbiota dysbiosis and CHF. Therefore, this review aims to explore the potential connection between dietary patterns, gut microbiota, and its metabolites in individuals at risk of CHF in the Asian population.
A literature review of cross-sectional studies was conducted using primary keywords such as "Asian", "obesity", "type 2 diabetes", "hypertension", "dyslipidemia", "coronary artery disease", and "chronic heart failure". There was no restriction on sample size.
Several gut microbiotas were found to correlate with CHF risk factors. There were increased levels of Prevotella, Klebsiella, Romboutsia, Catenibacterium, Clostridium, Holdemanella, Ruminococcus, Coprococcus, Parabacteroides, Bacteroides, Lachnoclostridium, Streptococcus, and Megamonas, while decreased levels of Oscillibacter, Bifidobacterium, Lactobacillus, Akkermansia, Roseburia, Faecalibacterium, Pseudobutyrivibrio, and Eubacterium were reported. These microbiota shifts were linked to increased TMAO production and impaired short-chain fatty acids (SCFAs) production. Dietary intake and microbial metabolites were also identified as contributors to the gut microbiota associated with CHF.
A potential link exists between the gut microbiota profile and CHF risk factors, possibly mediated by microbial metabolites. Dietary patterns may influence CHF-associated gut microbiota and me-tabolites. Future research is needed to investigate how dietary modifications can modulate gut microbiota and its metabolites in CHF patients.
慢性心力衰竭（CHF）是主要的心血管疾病之一，在亚洲人群中尤为如此。具有肥胖、2型糖尿病、高血压、血脂异常和冠状动脉疾病（CAD）等特定健康风险的个体更容易患CHF。目前关于理解肠道微生物群失调与CHF之间联系的证据有限。因此，本综述旨在探讨亚洲人群中CHF风险个体的饮食模式、肠道微生物群及其代谢产物之间的潜在联系。
使用“亚洲人”“肥胖”“2型糖尿病”“高血压”“血脂异常”“冠状动脉疾病”和“慢性心力衰竭”等主要关键词对横断面研究进行文献综述。对样本量没有限制。
发现几种肠道微生物群与CHF风险因素相关。普雷沃氏菌、克雷伯菌、罗姆布茨菌、链状杆菌、梭菌、霍尔德曼菌、瘤胃球菌、粪球菌、副拟杆菌、拟杆菌、毛螺菌、链球菌和巨单胞菌水平升高，而颤杆菌、双歧杆菌、乳酸杆菌、阿克曼菌、罗斯伯里亚菌、粪杆菌、假丁酸弧菌和真杆菌水平降低。这些微生物群的变化与氧化三甲胺（TMAO）产量增加和短链脂肪酸（SCFAs）产量受损有关。饮食摄入和微生物代谢产物也被确定为与CHF相关的肠道微生物群的促成因素。
肠道微生物群谱与CHF风险因素之间可能存在联系，可能由微生物代谢产物介导。饮食模式可能影响与CHF相关的肠道微生物群和代谢产物。未来需要开展研究以调查饮食调整如何调节CHF患者的肠道微生物群及其代谢产物。
