Zhang Shouyi, Shen Tao, Zeng Yu
Department of Urology, the Cancer Hospital of Dalian University of Technology & Liaoning Cancer Hospital, Shenyang 110042, China.
Department of Urology, Second Affiliated Hospital of Shenyang Medical College, No. 20 Beijiu Road, Heping District, Shenyang 110001, China.
Cancers (Basel). 2023 Apr 11;15(8):2243. doi: 10.3390/cancers15082243.
The gradual evolution of prostate tissue from benign tumor to malignant lesion or distant metastasis is driven by intracellular epigenetic changes and the tumor microenvironment remodeling. With the continuous study of epigenetic modifications, these tumor-driving forces are being discovered and are providing new treatments for cancer. Here we introduce the classification of epigenetic modification and highlight the role of epigenetic modification in tumor remodeling and communication of the tumor microenvironment.
前列腺组织从良性肿瘤逐渐演变为恶性病变或远处转移是由细胞内表观遗传变化和肿瘤微环境重塑驱动的。随着对表观遗传修饰的不断研究，这些肿瘤驱动因素正在被发现，并为癌症提供新的治疗方法。在此，我们介绍表观遗传修饰的分类，并强调表观遗传修饰在肿瘤重塑和肿瘤微环境通讯中的作用。
