Manzo Nicoletta, Ginatempo Francesca, Belvisi Daniele, Arcara Giorgio, Parrotta Ilaria, Leodori Giorgio, Deriu Franca, Celletti Claudia, Camerota Filippo, Conte Antonella
IRCCS San Camillo Hospital, Via Alberoni 70, 30126 Venice, Italy.
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43c, 07100 Sassari, Italy.
Brain Sci. 2023 Apr 15;13(4):664. doi: 10.3390/brainsci13040664.
: The ability to perceive two tactile stimuli as asynchronous can be measured using the somatosensory temporal discrimination threshold (STDT). In healthy humans, the execution of a voluntary movement determines an increase in STDT values, while the integration of STDT and movement execution is abnormal in patients with basal ganglia disorders. Sensorimotor integration can be modulated using focal muscle vibration (fMV), a neurophysiological approach that selectively activates proprioceptive afferents from the vibrated muscle. : In this study, we investigated whether fMV was able to modulate STDT or STDT-movement integration in healthy subjects by measuring them before, during and after fMV applied over the first dorsalis interosseous, abductor pollicis brevis and flexor radialis carpi muscles. : The results showed that fMV modulated STDT-movement integration only when applied over the first dorsalis interosseous, namely, the muscle performing the motor task involved in STDT-movement integration. These changes occurred during and up to 10 min after fMV. Differently, fMV did not influence STDT at rest. We suggest that that fMV interferes with the STDT-movement task processing, possibly disrupting the physiological processing of sensory information. : This study showed that FMV is able to modulate STDT-movement integration when applied over the muscle involved in the motor task. This result provides further information on the mechanisms underlying fMV, and has potential future implications in basal ganglia disorders characterized by altered sensorimotor integration.
可以使用体感时间辨别阈值（STDT）来测量将两个触觉刺激感知为异步的能力。在健康人群中，自主运动的执行会导致STDT值增加，而在基底神经节疾病患者中，STDT与运动执行的整合是异常的。感觉运动整合可以通过局部肌肉振动（fMV）进行调节，这是一种神经生理学方法，可选择性激活来自振动肌肉的本体感受传入神经。在本研究中，我们通过在第一骨间背侧肌、拇短展肌和桡侧腕屈肌上施加fMV之前、期间和之后测量STDT，来研究fMV是否能够调节健康受试者的STDT或STDT与运动的整合。结果表明，fMV仅在施加于第一骨间背侧肌时调节STDT与运动的整合，即参与STDT与运动整合的运动任务的肌肉。这些变化发生在fMV施加期间及之后长达10分钟。不同的是，fMV在静息状态下不影响STDT。我们认为fMV干扰了STDT与运动任务的处理，可能扰乱了感觉信息的生理处理。本研究表明，当fMV施加于参与运动任务的肌肉时，能够调节STDT与运动的整合。这一结果为fMV的潜在机制提供了进一步的信息，并且对以感觉运动整合改变为特征的基底神经节疾病具有潜在的未来意义。
