Conte Antonella, Belvisi Daniele, Tartaglia Matteo, Cortese Francesca Natalia, Baione Viola, Battista Emanuele, Zhu Xiao Y, Fabbrini Giovanni, Berardelli Alfredo
Department of Neurology and Psychiatry, Sapienza University Rome, Rome, Italy.
IRCCS Neuromed, Pozzilli, Italy.
Front Neurol. 2017 Jun 6;8:249. doi: 10.3389/fneur.2017.00249. eCollection 2017.
Evidence shows altered somatosensory temporal discrimination threshold (STDT) in Parkinson's disease in comparison to normal subjects. In healthy subjects, movement execution modulates STDT values through mechanisms of sensory gating. We investigated whether STDT modulation during movement execution in patients with Parkinson's disease differs from that in healthy subjects. In 24 patients with Parkinson's disease and 20 healthy subjects, we tested STDT at baseline and during index finger abductions (at movement onset "0", 100, and 200 ms thereafter). We also recorded kinematic features of index finger abductions. Fifteen out of the 24 patients were also tested ON medication. In healthy subjects, STDT increased significantly at 0, 100, and 200 ms after movement onset, whereas in patients with Parkinson's disease in OFF therapy, it increased significantly at 0 and 100 ms but returned to baseline values at 200 ms. When patients were tested ON therapy, STDT during index finger abductions increased significantly, with a time course similar to that of healthy subjects. Differently from healthy subjects, in patients with Parkinson's disease, the mean velocity of the finger abductions decreased according to the time lapse between movement onset and the delivery of the paired electrical stimuli for testing somatosensory temporal discrimination. In conclusion, patients with Parkinson's disease show abnormalities in the temporal coupling between tactile information and motor outflow. Our study provides first evidence that altered temporal processing of sensory information play a role in the pathophysiology of motor symptoms in Parkinson's disease.
证据表明，与正常受试者相比，帕金森病患者的体感时间辨别阈值（STDT）发生了改变。在健康受试者中，运动执行通过感觉门控机制调节STDT值。我们研究了帕金森病患者运动执行过程中的STDT调节是否与健康受试者不同。在24例帕金森病患者和20例健康受试者中，我们在基线时以及食指外展期间（运动开始时“0”，此后100和200毫秒）测试了STDT。我们还记录了食指外展的运动学特征。24例患者中有15例还在服药时进行了测试。在健康受试者中，运动开始后0、100和200毫秒时STDT显著增加，而在未接受治疗的帕金森病患者中，0和100毫秒时STDT显著增加，但在200毫秒时恢复到基线值。当患者在服药时进行测试时，食指外展期间的STDT显著增加，其时程与健康受试者相似。与健康受试者不同的是，在帕金森病患者中，食指外展的平均速度随着运动开始与用于测试体感时间辨别的配对电刺激发放之间的时间间隔而降低。总之，帕金森病患者在触觉信息与运动输出之间的时间耦合方面存在异常。我们的研究首次证明，感觉信息的时间处理改变在帕金森病运动症状的病理生理学中起作用。
