Donation Policy & Studies, Canadian Blood Services, Calgary, Alberta, Canada.
Donation Policy & Studies, Canadian Blood Services, Ottawa, Ontario, Canada.
Vox Sang. 2023 Aug;118(8):605-615. doi: 10.1111/vox.13443. Epub 2023 May 16.
In Canada, the time deferral for gay, bisexual and other men who have sex with men (gbMSM) to donate blood has gradually decreased. In September 2022, this deferral was replaced with sexual behaviour-based screening for all donors. We investigate how data from targeted research programmes addressed knowledge gaps to support this change.
We conducted a scoping review describing the Canadian literature available before the research programmes relating to (1) behavioural indicators of HIV risk and (2) attitudes to blood donation among gbMSM, current donors and the general population. We summarize the targeted research programmes, their outputs and impact to date.
For question 1, five projects met inclusion criteria. For question 2, three articles met inclusion criteria. Knowledge gaps identified were insufficient evidence of HIV incidence in gbMSM who met other donor eligibility criteria and scant data on opinions and views of blood donation and screening criteria for sexual risk behaviours. The research programmes funded 19 projects at 11 different research sites involving over 100 individual researchers/collaborators resulting in 19 peer-reviewed publications to date. Leveraging existing gbMSM cohorts yielded relevant HIV incidence data to inform safety modelling studies. Findings indicated that sexual behaviour-based screening was acceptable to gbMSM and donors, and donor discomfort around specific questions could be mitigated with clear explanations.
Targeted research programmes filled critical knowledge gaps and informed a change to gender-neutral, sexual behaviour-based screening for all donors. Findings supported successful implementation of these changes with research-informed staff training.
在加拿大,男同性恋、双性恋和其他与男性发生性关系的男性(gbMSM)献血的时间延迟逐渐减少。2022 年 9 月,对所有献血者采用基于性行为的筛查来取代这种延迟。我们调查了专门的研究计划如何提供数据来解决知识差距,以支持这一变化。
我们进行了一次范围界定综述,描述了与(1)艾滋病毒风险的行为指标和(2)gbMSM、当前献血者和一般人群对献血的态度相关的加拿大研究计划之前的可用文献。我们总结了专门的研究计划、它们的产出以及迄今为止的影响。
对于问题 1,有五个项目符合纳入标准。对于问题 2,有三篇文章符合纳入标准。确定的知识差距是,满足其他献血者资格标准的 gbMSM 中艾滋病毒发病率的证据不足,以及关于对献血和性行为筛查标准的意见和看法的数据稀少。这些研究计划资助了 11 个不同研究地点的 19 个项目,涉及 100 多名独立研究人员/合作者,迄今为止已产生 19 篇同行评审出版物。利用现有的 gbMSM 队列产生了相关的艾滋病毒发病率数据,为安全建模研究提供了信息。研究结果表明,基于性行为的筛查对 gbMSM 和献血者是可以接受的,并且可以通过清晰的解释来减轻对特定问题的献血者不适。
专门的研究计划填补了关键的知识空白,并为所有献血者采用基于性别中立和性行为的筛查提供了信息。研究结果支持在实施这些变化时进行研究为基础的员工培训。