Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Center of Biostatistics, Design, Measurement and Evaluation, Department of Clinical Research Management, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
PLoS One. 2023 May 16;18(5):e0285772. doi: 10.1371/journal.pone.0285772. eCollection 2023.
The primary aim is to determine the factors associated with breast cancer-related lymphedema and to identify new associated factors for the recurrence of breast cancer and depression. The secondary objective is to investigate the incidence of breast cancer-related events (breast cancer-related lymphedema, recurrence of breast cancer, and depression). Finally, we want to explore and validate the complex relationship among multiple factors influencing breast cancer complications and breast cancer recurrence.
A cohort study of females with unilateral breast cancer will be conducted in West China Hospital between February 2023 and February 2026. Breast cancer survivors in the age range of 17-55 will be recruited before breast cancer surgery. We will recruit 1557 preoperative patients with a first invasive breast cancer diagnosis. Consenting breast cancer survivors will complete demographic information, clinicopathological factors, surgery information, baseline information, and a baseline depression questionnaire. Data will be collected at four stages: the perioperative stage, chemotherapy therapy stage, radiation therapy stage, and follow-up stage. Data including the incidence and correlation of breast cancer-related lymphedema, breast cancer recurrence, depression, and medical cost will be collected and computed through the four stages above. For every statistical analysis, the participants will be classified into two groups based on whether they develop secondary lymphedema. Incidence rates of breast cancer recurrence and depression will be calculated separately for groups. Multivariate logistic regression will be used to determine whether secondary lymphedema and other parameters can predict breast cancer recurrence.
Our prospective cohort study will contribute to establishing an early detection program for breast cancer-related lymphedema and recurrence of breast cancer, which are both associated with poor quality of life and reduced life expectancy. Our study can also provide new insights into the physical, economic, treatment-related and mental burdens of breast cancer survivors.
本研究旨在确定与乳腺癌相关淋巴水肿相关的因素，并确定乳腺癌复发和抑郁的新相关因素。次要目标是调查乳腺癌相关事件（乳腺癌相关淋巴水肿、乳腺癌复发和抑郁）的发生率。最后，我们希望探索和验证影响乳腺癌并发症和乳腺癌复发的多个因素之间的复杂关系。
本研究为一项在华西医院进行的单侧乳腺癌女性队列研究，研究时间为 2023 年 2 月至 2026 年 2 月。将招募年龄在 17-55 岁之间的乳腺癌幸存者在乳腺癌手术前。我们将招募 1557 名首次接受浸润性乳腺癌诊断的术前患者。同意参与的乳腺癌幸存者将完成人口统计学信息、临床病理因素、手术信息、基线信息和基线抑郁问卷。数据将在四个阶段收集：围手术期、化疗阶段、放疗阶段和随访阶段。将收集包括乳腺癌相关淋巴水肿、乳腺癌复发、抑郁和医疗费用的发生率和相关性在内的数据。对于每一项统计分析，参与者将根据是否发生继发性淋巴水肿分为两组。将分别计算乳腺癌复发和抑郁组的发生率。将使用多变量逻辑回归来确定继发性淋巴水肿和其他参数是否可以预测乳腺癌复发。
我们的前瞻性队列研究将有助于建立乳腺癌相关淋巴水肿和乳腺癌复发的早期检测计划，这两者都与生活质量差和预期寿命缩短有关。我们的研究还可以为乳腺癌幸存者的身体、经济、治疗相关和心理负担提供新的见解。
