癌症及其他病症中的己糖激酶

Hexokinases in cancer and other pathologies.

作者信息

Guo Dong, Meng Ying, Jiang Xiaoming, Lu Zhimin

机构信息

Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China.

出版信息

Cell Insight. 2023 Jan 3;2(1):100077. doi: 10.1016/j.cellin.2023.100077. eCollection 2023 Feb.

DOI:10.1016/j.cellin.2023.100077

PMID:37192912

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10120283/

Abstract

Glucose metabolism is indispensable for cell growth and survival. Hexokinases play pivotal roles in glucose metabolism through canonical functions of hexokinases as well as in immune response, cell stemness, autophagy, and other cellular activities through noncanonical functions. The aberrant regulation of hexokinases contributes to the development and progression of pathologies, including cancer and immune diseases.

摘要

葡萄糖代谢对于细胞生长和存活至关重要。己糖激酶通过其经典功能在葡萄糖代谢中发挥关键作用，同时也通过非经典功能参与免疫反应、细胞干性、自噬及其他细胞活动。己糖激酶的异常调节会导致包括癌症和免疫疾病在内的多种病理状况的发生和发展。