Departments of Hepatobiliary and Pancreatic Surgery, The Dingli Clinical Institute of Wenzhou Medical University (Wenzhou Central Hospital), Wenzhou, Zhejiang Province, People's Republic of China.
Departments of Pathology, The Dingli Clinical Institute of Wenzhou Medical University (Wenzhou Central Hospital), Wenzhou, Zhejiang Province, People's Republic of China.
World J Surg Oncol. 2023 May 17;21(1):150. doi: 10.1186/s12957-023-03025-6.
BACKGROUND/AIM: This study investigated the clinicopathological characteristics and treatment of appendix neuroendocrine neoplasms in appendectomy specimens of our center.
The clinicopathological data, including age, sex, preoperative clinical manifestation, surgical method, and histopathological examination results of 11 patients with appendix neuroendocrine neoplasms confirmed by surgery and pathology between November 2005 and January 2023, were retrospectively analyzed.
In the histopathological examination of 7277 appendectomy specimens, 11 cases (0.2%) had appendix neuroendocrine neoplasms. Among the 11 patients, 8(72.7%) were males, and 3(27.3%) were females, with an average age of 48.1 years. All patients underwent emergency surgery. A total of 9 patients underwent open appendectomy, including 1 patient who underwent second-stage simple right hemicolectomy after an appendectomy, and two who underwent laparoscopic appendectomy. All 11 patients were followed up for a period of 1 to 17 years. All patients survived without any indication of tumor recurrence.
Appendiceal neuroendocrine neoplasms are low-grade malignant tumors originating from neuroendocrine cells. They are rarely seen in clinical practice and are often treated based on acute and chronic appendicitis symptoms. These tumors are challenging to diagnose before surgery due to the lack of specificity in clinical manifestations and auxiliary examinations. The diagnosis generally depends on postoperative pathology and immunohistochemistry. Despite the diagnostic challenges, these tumors have a favorable prognosis.
背景/目的：本研究旨在探讨我院阑尾切除标本中阑尾神经内分泌肿瘤的临床病理特征及治疗方法。
回顾性分析 2005 年 11 月至 2023 年 1 月期间，经手术和病理证实的 11 例阑尾神经内分泌肿瘤患者的临床病理资料，包括年龄、性别、术前临床表现、手术方式及组织病理学检查结果。
在 7277 例阑尾切除标本的组织病理学检查中，发现 11 例（0.2%）阑尾神经内分泌肿瘤。11 例患者中，男性 8 例（72.7%），女性 3 例（27.3%），平均年龄 48.1 岁。所有患者均行急诊手术，其中 9 例行开腹阑尾切除术，包括 1 例行阑尾切除术后二期单纯右半结肠切除术，2 例行腹腔镜阑尾切除术。11 例患者均获得随访，随访时间 1~17 年，均存活，无肿瘤复发迹象。
阑尾神经内分泌肿瘤是起源于神经内分泌细胞的低度恶性肿瘤，临床少见，多根据急、慢性阑尾炎的症状进行治疗。由于临床表现和辅助检查缺乏特异性，这些肿瘤在术前难以诊断，一般依赖于术后病理和免疫组织化学检查。尽管诊断具有挑战性，但这些肿瘤预后良好。
