Faculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Elife. 2023 May 17;12:e84312. doi: 10.7554/eLife.84312.
Early-life experiences may promote stereotyped behavioral alterations that are dynamic across development time, but also behavioral responses that are variable among individuals, even when initially exposed to the same stimulus. Here, by utilizing longitudinal monitoring of individuals throughout development we show that behavioral effects of early-life starvation are exposed during early and late developmental stages and buffered during intermediate stages of development. We further found that both dopamine and serotonin shape the discontinuous behavioral responses by opposite and temporally segregated functions across development time. While dopamine buffers behavioral responses during intermediate developmental stages, serotonin promotes behavioral sensitivity to stress during early and late stages. Interestingly, unsupervised analysis of individual biases across development uncovered multiple individuality dimensions that coexist within stressed and unstressed populations and further identified experience-dependent effects on variation within specific individuality dimensions. These results provide insight into the complex temporal regulation of behavioral plasticity across developmental timescales, structuring shared and unique individual responses to early-life experiences.
早期生活经历可能会促进刻板的行为改变，这些改变在发展时间上是动态的，但也会导致个体之间的行为反应存在差异，即使他们最初受到相同的刺激。在这里，我们通过在整个发展过程中对个体进行纵向监测，表明早期生活饥饿的行为影响会在早期和晚期发育阶段暴露出来，并在中间发育阶段得到缓冲。我们还发现，多巴胺和血清素通过在发育时间上的相反和时间分离的功能来塑造不连续的行为反应。虽然多巴胺在中间发育阶段缓冲行为反应，但血清素在早期和晚期阶段促进对压力的行为敏感性。有趣的是，对个体在整个发育过程中的偏差的无监督分析揭示了多个存在于有压力和无压力群体中的个体性维度，并进一步确定了对特定个体性维度内变异性的经验依赖性影响。这些结果提供了对发育时间尺度上行为可塑性的复杂时间调节的深入了解，构建了对早期生活经历的共享和独特个体反应。
