Özkoca Defne, Caf Nazlı, Alacagöz Yılmaz Nazan Nur, Uzunçakmak Tuğba Kevser, Özdil Ayşenur, Atsü Ayşe Nilhan
Zonguldak Atatürk State Hospital, Dermatology and Venerology Clinic, Zonguldak, Turkey.
Diyarbakır Dağkapı Military Hospital, Dermatology and Venerology Clinic, Diyarbakır, Turkey.
Dermatol Pract Concept. 2023 Apr 1;13(2). doi: 10.5826/dpc.1302a121.
Systemic isotretinoin is the most effective treatment modality in acne vulgaris; however, both patients and physicians hesitate to use it due its side effects.
The aim of this study is to determine the prevalence of fatigue, myalgia and low back pain during systemic isotretinoin treatment; and to determine their relationship with age, gender, treatment duration, daily isotretinoin dose and isotretinoin-naiveness of the patient.
This is a cross sectional study including the acne vulgaris patients, aged between 13 to 40 years, who have at least received one month of oral isotretinoin treatment. Patients were questioned for side effects during their follow-up visits; a physical therapy and rehabilitation specialist further evaluated patients complaining of low back pain.
Fatigue was reported by 4.4% of the patients, myalgia by 2.8% and low back pain by 25% of the patients; 2.2% had inflammatory and 22.8% had mechanical low back pain. None of the patients had sacroiliitis. All the side effects that were examined were found to be independent of age, gender, isotretinoin dosage (mg/kg/day), treatment duration and isotretinoin-naiveness.
The side effects are not as common as feared; thus, patients and physicians should not hesitate to use systemic isotretinoin in indicated cases.
系统性异维A酸是寻常痤疮最有效的治疗方式；然而，由于其副作用，患者和医生都对使用它有所顾虑。
本研究旨在确定系统性异维A酸治疗期间疲劳、肌痛和腰痛的发生率；并确定它们与年龄、性别、治疗时长、每日异维A酸剂量以及患者是否初次使用异维A酸之间的关系。
这是一项横断面研究，纳入年龄在13至40岁之间、至少接受过一个月口服异维A酸治疗的寻常痤疮患者。在随访期间询问患者是否有副作用；一名物理治疗与康复专家对主诉腰痛的患者进行了进一步评估。
4.4%的患者报告有疲劳，2.8%报告有肌痛，25%报告有腰痛；2.2%有炎性腰痛，22.8%有机械性腰痛。没有患者患有骶髂关节炎。所有检查的副作用均与年龄、性别、异维A酸剂量（毫克/千克/天）、治疗时长以及是否初次使用异维A酸无关。
副作用并不像担心的那么常见；因此，在适应证明确的情况下，患者和医生不应犹豫使用系统性异维A酸。
