Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China.
Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 119074, Singapore.
Chem Soc Rev. 2022 Sep 20;51(18):7692-7714. doi: 10.1039/d2cs00131d.
Biomedical fluorescence imaging in the second near-infrared (NIR-II, 100-1700 nm) window provides great potential for visualizing physiological and pathological processes, owing to the reduced tissue absorption, scattering, and autofluorescence. Various types of NIR-II probes have been reported in the past decade. Among them, NIR-II organic/inorganic nanohybrids have attracted widespread attention due to their unique properties by integrating the advantages of both organic and inorganic species. Versatile organic/inorganic nanohybrids provide the possibility of realizing a combination of functions, controllable size, and multiple optical features. This tutorial review summarizes the reported organic and inorganic species in nanohybrids, and their biomedical applications in NIR-II fluorescence and lifetime imaging. Finally, the challenges and outlook of organic/inorganic nanohybrids in biomedical applications are discussed.
生物医学荧光成像是在近红外二区（NIR-II，100-1700nm）窗口进行的，由于组织吸收、散射和自发荧光的减少，该成像技术在可视化生理和病理过程方面具有很大的潜力。在过去的十年中，已经报道了各种类型的 NIR-II 探针。其中，由于整合了有机和无机物种的优势，NIR-II 有机/无机纳米杂化材料具有独特的性质，因此引起了广泛的关注。多功能的有机/无机纳米杂化材料为实现功能组合、可控尺寸和多种光学特性提供了可能性。本综述总结了纳米杂化材料中报道的有机和无机物种，以及它们在 NIR-II 荧光和寿命成像中的生物医学应用。最后，讨论了有机/无机纳米杂化材料在生物医学应用中的挑战和展望。
