Zorn T M, Bevilacqua E M, Abrahamsohn P A
Cell Tissue Res. 1986;244(2):443-8. doi: 10.1007/BF00219220.
An ultrastructural study of the features and distribution of collagen fibrils was performed in the endometrium of virgin and pregnant (2nd to 11th day) mice. Collagen-containing structures were observed in the cytoplasm of fibroblasts on the 2nd day of pregnancy. Treatment of tissues with lanthanum nitrate established that these structures were intracytoplasmic. Their association with lysosome-like bodies suggested the occurrence of intracellular digestion of collagen, probably connected with remodeling of the endometrial stroma prior to decidualization. On the 4th day of pregnancy, very few collagen fibrils were present in the intercellular space. From the 6th day of pregnancy onwards, "thick" collagen fibrils were observed between decidual cells. The diameter of these fibrils measured up to 300 nm whereas the fibrils present in the endometrium of virgin mice measured 40-68 nm.
对未孕和怀孕（第2至11天）小鼠的子宫内膜进行了胶原纤维特征和分布的超微结构研究。在怀孕第2天，在成纤维细胞的细胞质中观察到含胶原的结构。用硝酸镧处理组织表明这些结构位于胞质内。它们与溶酶体样小体的关联提示胶原发生了细胞内消化，这可能与蜕膜化前子宫内膜基质的重塑有关。在怀孕第4天，细胞间空间中存在的胶原纤维很少。从怀孕第6天起，在蜕膜细胞之间观察到“粗”胶原纤维。这些纤维的直径达300 nm，而未孕小鼠子宫内膜中的纤维直径为40 - 68 nm。
