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辉瑞-BioNTech 新冠疫苗(BNT162b2 mRNA)接种后出现格林-巴利综合征。

Guillain-Barré Syndrome Following the BNT162b2 mRNA COVID-19 Vaccine.

机构信息

Neurology Section, Department of Medicine, King Abdulaziz Medical City, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

Department of Neuroscience, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia.

出版信息

Acta Neurol Taiwan. 2023 Jun 30;32(2):82-85.

PMID:37198513
Abstract

PURPOSE

The onset of the COVID-19 (SARS-CoV-2) pandemic in December 2019 created the need for multiple scientific research activities and clinical trials in an attempt to find solutions to mitigate the impact of the virus. One of the important tools to combat the virus is the development of vaccination programs. All types of vaccines have been associated with a mild to severe risk of neurological adverse events. One of these severe adverse events is Guillain-Barré syndrome.

CASE REPORT

Here, we describe a case of Guillain-Barré syndrome after the first dose of the BNT162b2 mRNA COVID-19 vaccine and review the literature to increase the current knowledge regarding this complication.

CONCLUSION

Guillain-Barré syndrome after COVID-19 vaccination is responsive to treatment. The benefits of administering the vaccine outweigh the risks. Due to the negative impact of COVID-19, it is essential to recognize the development of neurological complications that are potentially associated with vaccination, including Guillain-Barré syndrome.

摘要

目的

2019 年 12 月,COVID-19(SARS-CoV-2)大流行的爆发催生了多项科学研究活动和临床试验,试图寻找减轻病毒影响的解决方案。对抗病毒的重要手段之一是开发疫苗接种计划。所有类型的疫苗都与轻度至重度的神经不良事件风险相关。其中一种严重的不良事件是吉兰-巴雷综合征。

病例报告

在这里,我们描述了一例首例 BNT162b2 mRNA COVID-19 疫苗接种后发生的吉兰-巴雷综合征病例,并回顾了文献,以增加对该并发症的现有认识。

结论

COVID-19 疫苗接种后发生的吉兰-巴雷综合征对治疗有反应。接种疫苗的益处大于风险。由于 COVID-19 的负面影响,必须认识到与接种相关的潜在神经并发症的发生,包括吉兰-巴雷综合征。

相似文献

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Guillain-Barré Syndrome Following the BNT162b2 mRNA COVID-19 Vaccine.辉瑞-BioNTech 新冠疫苗(BNT162b2 mRNA)接种后出现格林-巴利综合征。
Acta Neurol Taiwan. 2023 Jun 30;32(2):82-85.
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Guillain-Barré Syndrome Following the mRNA COVID-19 Vaccination: Comment.mRNA COVID-19 疫苗接种后出现格林-巴利综合征:评论。
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Sensory Ataxic Guillain-Barré Syndrome with Dysgeusia after mRNA COVID-19 Vaccination.mRNA COVID-19 疫苗接种后出现感觉运动性共济失调型吉兰-巴雷综合征伴味觉障碍
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Associations of Guillain-Barré syndrome with coronavirus disease 2019 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database.新型冠状病毒疾病 2019 疫苗接种与格林-巴利综合征的关联:使用世界卫生组织药物警戒数据库进行的比例失调分析。
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Guillain-Barré syndrome is infrequent among recipients of the BNT162b2 mRNA COVID-19 vaccine.在接种 BNT162b2 mRNA COVID-19 疫苗的人群中,格林-巴利综合征并不常见。
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Incidence of Guillain-Barré Syndrome After COVID-19 Vaccination in the Vaccine Safety Datalink.疫苗安全数据链接中 COVID-19 疫苗接种后吉兰-巴雷综合征的发生率。
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Guillain-Barré syndrome temporally associated with COVID-19 vaccines in Victoria, Australia.与澳大利亚维多利亚州 COVID-19 疫苗相关的吉兰-巴雷综合征。
Vaccine. 2022 Dec 12;40(52):7579-7585. doi: 10.1016/j.vaccine.2022.10.084. Epub 2022 Nov 7.

引用本文的文献

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Pharmacol Res Perspect. 2024 Oct;12(5):e70008. doi: 10.1002/prp2.70008.
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mRNA-LNP COVID-19 Vaccine Lipids Induce Complement Activation and Production of Proinflammatory Cytokines: Mechanisms, Effects of Complement Inhibitors, and Relevance to Adverse Reactions.mRNA-LNP COVID-19 疫苗脂质诱导补体激活和促炎细胞因子的产生:机制、补体抑制剂的作用及与不良反应的相关性。
Int J Mol Sci. 2024 Mar 22;25(7):3595. doi: 10.3390/ijms25073595.
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Guillain-Barre syndrome following COVID-19 vaccination: a study of 70 case reports.
新冠病毒疫苗接种后吉兰-巴雷综合征:70例病例报告研究
Ann Med Surg (Lond). 2024 Mar 6;86(4):2067-2080. doi: 10.1097/MS9.0000000000001915. eCollection 2024 Apr.