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混合闭环系统可以帮助那些极度担心低血糖或高血糖的患者。

Hybrid closed-loop systems can help patients with extreme fear of hypoglycemia or hyperglycemia.

机构信息

Department of Endocrinology and Nutrition, Hospital de la Santa Creu I Sant Pau, C/Sant Quintí 89, 08042, Barcelona, Spain.

CIBER-BBN, Instituto de Salud Carlos III, Madrid, Spain.

出版信息

Hormones (Athens). 2023 Sep;22(3):453-456. doi: 10.1007/s42000-023-00451-9. Epub 2023 May 17.

DOI:10.1007/s42000-023-00451-9
PMID:37198528
Abstract

Fear of hypoglycemia and hyperglycemia can lead to inappropriate diabetes self-management and untoward health outcomes. We report two patients, representative of these opposite conditions, who benefited from hybrid closed-loop technology. In the patient with fear of hypoglycemia, time in range improved from 26 to 56% and the patient did not present with severe hypoglycemia. Meanwhile, the patient with hyperglycemia aversiveness had a drastic reduction in time below range, from 19 to 4%. We conclude that hybrid closed-loop technology was an effective tool for improvement of glucose values in two patients with fear of hypoglycemia and hyperglycemia aversiveness, respectively.

摘要

对低血糖和高血糖的恐惧可能导致不当的糖尿病自我管理和不良的健康结果。我们报告了两位患者的案例,他们分别代表了这两种相反的情况,并从混合闭环技术中受益。在对低血糖恐惧的患者中,时间达标率从 26%提高到了 56%,且该患者未出现严重低血糖。同时,对高血糖反感的患者,其血糖低于目标范围的时间从 19%大幅减少到了 4%。我们得出结论,混合闭环技术是改善两名患者血糖值的有效工具,其中一名患者对低血糖恐惧,另一名患者对高血糖反感。

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本文引用的文献

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touchREV Endocrinol. 2022 Jun;18(1):27-34. doi: 10.17925/EE.2022.18.1.27. Epub 2022 May 20.
2
Patient-Reported Outcomes in a Randomized Trial of Closed-Loop Control: The Pivotal International Diabetes Closed-Loop Trial.患者报告结局的随机试验闭环控制:关键的国际糖尿病闭环试验。
Diabetes Technol Ther. 2021 Oct;23(10):673-683. doi: 10.1089/dia.2021.0089.
3
"Hyperglycemia aversiveness": Investigating an overlooked problem among adults with type 1 diabetes.
“对高血糖的厌恶”:在 1 型糖尿病成人中调查一个被忽视的问题。
J Diabetes Complications. 2021 Jun;35(6):107925. doi: 10.1016/j.jdiacomp.2021.107925. Epub 2021 Mar 29.
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Diabetologia. 2021 May;64(5):1007-1015. doi: 10.1007/s00125-021-05391-w. Epub 2021 Feb 6.
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Diabeloop DBLG1 Closed-Loop System Enables Patients With Type 1 Diabetes to Significantly Improve Their Glycemic Control in Real-Life Situations Without Serious Adverse Events: 6-Month Follow-up.Diabeloop DBLG1 闭环系统使 1 型糖尿病患者在真实情况下显著改善血糖控制,且无严重不良事件:6 个月随访结果。
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Fear of hypoglycemia in adults with type 1 diabetes: impact of therapeutic advances and strategies for prevention - a review.1型糖尿病成人患者的低血糖恐惧:治疗进展的影响及预防策略——综述
J Diabetes Complications. 2016 Jan-Feb;30(1):167-77. doi: 10.1016/j.jdiacomp.2015.09.003. Epub 2015 Sep 7.
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Psychosocial aspects of closed- and open-loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting.闭环和开环胰岛素给药的社会心理方面:在家庭环境中为1型糖尿病成人患者实现闭环给药
Diabet Med. 2015 May;32(5):601-8. doi: 10.1111/dme.12706. Epub 2015 Feb 20.