Magendarm Thalwil AG, Zürcherstrasse 61, Thalwil, 8800, Switzerland.
University of Basel, Klingelbergstrasse 61, Basel, 4056, Switzerland.
BMC Geriatr. 2023 May 17;23(1):303. doi: 10.1186/s12877-023-03959-2.
Worldwide population is ageing, but little is known regarding risk factors associated with increased mortality in subjectively healthy, community-dwelling older adults. We present the updated results of the longest follow-up carried out on Swiss pensioners and we provide results on potential risk factors associated with mortality before the onset of the COVID-19 pandemic.
Within the SENIORLAB study, we collected demographic data, anthropometric measures, medical history, and laboratory parameters of 1467 subjectively healthy, community-dwelling, Swiss adults aged ≥ 60 years over a median follow-up of 8.79 years. The variables considered in the multivariable Cox-proportional hazard model for mortality during follow-up were selected based on prior knowledge. Two separate models for males and females were calculated; moreover, we fitted the old model obtained in 2018 to the complete follow-up data to highlight differences and similarities.
The population sample included 680 males and 787 females. Age of participants ranged between 60 and 99 years. We experienced 208 deaths throughout the entire follow-up period; no patients were lost at follow-up. The Cox-proportional hazard regression model included female gender, age, albumin levels, smoking status, hypertension, osteoporosis and history of cancer within predictors of mortality over the follow-up period. Consistent findings were obtained also after gender stratification. After fitting the old model, female gender, hypertension, and osteoporosis still showed statistically significant independent associations with all-cause mortality.
Understanding the predictors of a healthy survival can improve the overall quality of life of the ageing population and simultaneously reduce their global economic burden.
The present study was registered in the International Standard Randomized Controlled Trial Number registry: https://www.isrctn.com/ISRCTN53778569 (registration date: 27/05/2015).
全球人口正在老龄化，但对于主观健康、居住在社区的老年人中与死亡率增加相关的风险因素知之甚少。我们展示了对瑞士养老金领取者进行的最长随访的最新结果，并提供了 COVID-19 大流行前与死亡率相关的潜在风险因素的结果。
在 SENIORLAB 研究中，我们收集了 1467 名主观健康、居住在社区的瑞士成年人的人口统计学数据、人体测量数据、病史和实验室参数，年龄均≥60 岁，中位随访时间为 8.79 年。在随访期间用于死亡率的多变量 Cox 比例风险模型中考虑的变量是基于先前的知识选择的。为男性和女性分别计算了两个单独的模型；此外，我们还拟合了 2018 年获得的旧模型，以突出差异和相似之处。
该人群样本包括 680 名男性和 787 名女性。参与者的年龄在 60 至 99 岁之间。在整个随访期间，我们共经历了 208 例死亡，无患者失访。Cox 比例风险回归模型包括女性性别、年龄、白蛋白水平、吸烟状况、高血压、骨质疏松症和癌症史，作为预测死亡率的因素。在性别分层后也得到了一致的发现。拟合旧模型后，女性性别、高血压和骨质疏松症仍然与全因死亡率有统计学上的显著独立关联。
了解健康生存的预测因素可以提高老年人口的整体生活质量，同时减轻他们的全球经济负担。
本研究在国际标准随机对照试验编号注册中心注册：https://www.isrctn.com/ISRCTN53778569（注册日期：2015 年 5 月 27 日）。
