乳腺癌前哨淋巴结活检中吲哚菁绿与亚甲蓝联合应用的临床研究。
Clinical study of combined application of indocyanine green and methylene blue for sentinel lymph node biopsy in breast cancer.
机构信息
Department of Breast Surgery, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
出版信息
Medicine (Baltimore). 2021 Apr 16;100(15):e25365. doi: 10.1097/MD.0000000000025365.
OBJECTIVE
This study aims to investigate the feasibility of combined application of indocyanine green (ICG) and methylene blue (MB) for sentinel lymph node biopsy (SLNB) in patients with early breast cancer.
METHODS
A total of 415 patients who underwent SLNB and axillary lymph node dissection were enrolled. Sentinel lymph node (SLN) was assessed in 197 patients with ICG and MB combination method, while, the other 218 patients were detected by MB method alone. During surgery, all SLNs were harvested for pathological examination. Then the detection rate and false negative rate of SLNs were comparatively analyzed between the 2 groups.
RESULTS
In the combined ICG and MB group, the detection rate of SLNs was 96.9%, significantly higher than that of MB group, which was 89.7% (P < .05). Similarly, in combined group, the average number of SLNs per patient was 3.0, much higher than that of MB group, which was 2.1 (P < .05). There was no statistically significant difference in false negative rate between combined group and MB alone group, which was 7.3% and 10.5%, respectively (P = .791).
CONCLUSION
The combined application of ICG and MB for SLNB is much more effective than MB alone in detecting SLNs.
目的
本研究旨在探讨吲哚菁绿（ICG）和亚甲蓝（MB）联合应用于早期乳腺癌前哨淋巴结活检（SLNB）的可行性。
方法
共纳入 415 例接受 SLNB 和腋窝淋巴结清扫术的患者。197 例患者采用 ICG 和 MB 联合方法评估前哨淋巴结（SLN），另 218 例患者仅采用 MB 方法检测。术中均采集所有 SLN 进行病理检查。然后比较两组 SLN 的检出率和假阴性率。
结果
在 ICG 和 MB 联合组中，SLN 的检出率为 96.9%，明显高于 MB 组的 89.7%（P<0.05）。同样，在联合组中，每位患者的平均 SLN 数为 3.0，明显高于 MB 组的 2.1（P<0.05）。联合组和 MB 组的假阴性率分别为 7.3%和 10.5%，差异无统计学意义（P=0.791）。
结论
ICG 和 MB 联合应用于 SLNB 检测 SLN 比 MB 单独应用更有效。
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