Zhejiang Chinese Medical University, Hangzhou, China.
Department of Diagnostic Ultrasound Imaging & Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.
Cancer Med. 2023 Jul;12(13):14305-14316. doi: 10.1002/cam4.6107. Epub 2023 May 18.
Papillary thyroid carcinoma (PTC) has a high propensity for cervical lymph node metastasis (CLNM). We evaluated the association between PTC radio frequency (RF) signals and CLNM.
Patients with PTC (n = 170) confirmed by pathology after thyroidectomy between July 2019 and May 2022 were enrolled in this retrospective cohort study. Patients were divided into positive and negative groups according to CLNM. Univariate analysis was performed to predict CLNM and a receiver operating characteristic (ROC) curve was generated to evaluate the diagnostic performance of RF signals and the Thyroid imaging Reporting and Data System.
Of 170 patients with 182 nodules included in the study, 11 had multiple nodules. Univariate analysis showed that age, maximum tumor diameter, cross-sectional and longitudinal aspect ratio, RF quantitative parameters (cross-sectional intercept, mid-band, S1, and S4, and longitudinal Higuchi, slope, intercept, mid-band, S1), and echogenic foci were independently associated with CLNM (p < 0.05). The area under the curve (AUC) values of the maximum tumor diameter, longitudinal slope, and echogenic foci were 0.68, 0.61, and 0.62, respectively. Linear regression analysis of maximum tumor diameter, longitudinal slope, and echogenic foci showed that the correlations between longitudinal slope and CLNM were greater than that of echogenic foci (ß = 0.203 vs. ß = 0.154).
Longitudinal slope and echogenic foci have similar diagnostic efficacy for predicting the risk of CLNM in PTC, although longitudinal slope has a greater correlation with CLNM.
甲状腺乳头状癌（PTC）具有较高的颈淋巴结转移（CLNM）倾向。我们评估了 PTC 射频（RF）信号与 CLNM 之间的关系。
本回顾性队列研究纳入了 2019 年 7 月至 2022 年 5 月期间经手术病理证实为 PTC 的 170 例患者。根据 CLNM 将患者分为阳性组和阴性组。采用单因素分析预测 CLNM，并生成受试者工作特征（ROC）曲线以评估 RF 信号和甲状腺影像报告和数据系统的诊断性能。
在纳入研究的 170 例患者的 182 个结节中，有 11 例为多个结节。单因素分析显示，年龄、最大肿瘤直径、横径与长径比、RF 定量参数（横径截距、中带、S1 和 S4，以及长径 Higuchi、斜率、截距、中带、S1）和回声焦点与 CLNM 独立相关（p<0.05）。最大肿瘤直径、长径斜率和回声焦点的曲线下面积（AUC）值分别为 0.68、0.61 和 0.62。最大肿瘤直径、长径斜率和回声焦点的线性回归分析显示，长径斜率与 CLNM 的相关性大于回声焦点（β=0.203 比 β=0.154）。
尽管长径斜率与 CLNM 的相关性更强，但长径斜率和回声焦点对预测 PTC CLNM 风险具有相似的诊断效能。
