State Key Laboratory of Microbial Technology, Shandong University, 72 Binhai Road, Qingdao 266237, Shandong, P. R. China.
School of Chemistry and Environment, Jiaying University, Meizhou 514015, Guangdong, P. R. China.
Chem Commun (Camb). 2023 Jun 1;59(45):6893-6896. doi: 10.1039/d3cc01551c.
Herein we develop a Ni-catalyzed defluorinative cross-electrophile coupling of -difluoroalkenes with alkenyl electrophiles that allowed the generation of C(sp)-C(sp) bonds. The reaction provided various monofluoro 1,3-dienes with broad functional group compatibility and excellent stereoselectivity. Synthetic transformations and applications to the modification of complex compounds were also demonstrated.
在此，我们开发了一种镍催化的 -二氟烯烃与烯基亲电试剂的脱氟交叉偶联反应，该反应可以生成 C(sp)-C(sp)键。该反应提供了具有广泛官能团兼容性和优异立体选择性的各种单氟 1,3-二烯。还展示了合成转化和在复杂化合物修饰中的应用。
