Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya 464-8601, Japan.
Org Biomol Chem. 2023 Jun 7;21(22):4587-4590. doi: 10.1039/d3ob00647f.
The ABCD ring system of C/C diterpene alkaloids was constructed cationic [5 + 2] cycloaddition to forge a bicyclo[3.2.1]octane, an intramolecular aldol reaction to form a seven-membered ring, oxidation of a phenol at the -position, and introduction of a one-carbon unit Stille coupling followed by oxidative cleavage of a furan ring.
C/C 二萜生物碱的 ABCD 环系通过阳离子 [5 + 2] 环加成形成二环[3.2.1]辛烷，分子内羟醛反应形成七元环，-位酚的氧化以及一碳单元的引入 通过 Stille 偶联反应，随后呋喃环的氧化裂解。
